Early histopathological changes in new-onset diabetes after kidney transplantation

B. Borda, Y. Munir Ibrahim, C. Lengyel, T. Várkonyi, A. Kubik, C. Keresztes, G. Lazar

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background. New-onset diabetes after transplantation (NODAT) is one of the most common complications after kidney transplantation. Methods. Patients were randomly assigned to receive cyclosporine A-based or tacrolimus-based immunosuppression. Fasting and oral glucose tolerance tests were performed, and the patients were assigned to one of the following 3 groups, on the basis of the results: normal, impaired fasting glucose/impaired glucose tolerance, or NODAT. NODAT developed in 14% of patients receiving cyclosporine A-based immunosuppression and in 26% of patients taking tacrolimus (P =.0002). Results. Albumin levels were similar, but uric acid level (P =.002) and the age of the recipient (P =.003) were significantly different between the diabetic and the normal groups. Evaluation of tissue samples revealed that acute cellular rejection and interstitial fibrosis/tubular atrophy were significantly different in the NODAT group. Changes in the Banff score provided significant difference regarding tubulitis and interstitial inflammation (P =.05). Conclusions. The pathological effect of new-onset diabetes after kidney transplantation can be detected in the morphology of the renal allograft earlier, before the development of any sign of functional impairment.

Original languageEnglish
Pages (from-to)2155-2159
Number of pages5
JournalTransplantation Proceedings
Volume46
Issue number6
DOIs
Publication statusPublished - 2014

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Kidney Transplantation
Transplantation
Tacrolimus
Immunosuppression
Cyclosporine
Fasting
Glucose Intolerance
Glucose Tolerance Test
Uric Acid
Atrophy
Allografts
Albumins
Fibrosis
Inflammation
Kidney
Glucose

ASJC Scopus subject areas

  • Surgery
  • Transplantation
  • Medicine(all)

Cite this

Early histopathological changes in new-onset diabetes after kidney transplantation. / Borda, B.; Munir Ibrahim, Y.; Lengyel, C.; Várkonyi, T.; Kubik, A.; Keresztes, C.; Lazar, G.

In: Transplantation Proceedings, Vol. 46, No. 6, 2014, p. 2155-2159.

Research output: Contribution to journalArticle

Borda, B. ; Munir Ibrahim, Y. ; Lengyel, C. ; Várkonyi, T. ; Kubik, A. ; Keresztes, C. ; Lazar, G. / Early histopathological changes in new-onset diabetes after kidney transplantation. In: Transplantation Proceedings. 2014 ; Vol. 46, No. 6. pp. 2155-2159.
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AU - Várkonyi, T.

AU - Kubik, A.

AU - Keresztes, C.

AU - Lazar, G.

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N2 - Background. New-onset diabetes after transplantation (NODAT) is one of the most common complications after kidney transplantation. Methods. Patients were randomly assigned to receive cyclosporine A-based or tacrolimus-based immunosuppression. Fasting and oral glucose tolerance tests were performed, and the patients were assigned to one of the following 3 groups, on the basis of the results: normal, impaired fasting glucose/impaired glucose tolerance, or NODAT. NODAT developed in 14% of patients receiving cyclosporine A-based immunosuppression and in 26% of patients taking tacrolimus (P =.0002). Results. Albumin levels were similar, but uric acid level (P =.002) and the age of the recipient (P =.003) were significantly different between the diabetic and the normal groups. Evaluation of tissue samples revealed that acute cellular rejection and interstitial fibrosis/tubular atrophy were significantly different in the NODAT group. Changes in the Banff score provided significant difference regarding tubulitis and interstitial inflammation (P =.05). Conclusions. The pathological effect of new-onset diabetes after kidney transplantation can be detected in the morphology of the renal allograft earlier, before the development of any sign of functional impairment.

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