Early hemorheological changes in a porcine model of intravenously given E. coli induced fulminant sepsis

Norbert Nemeth, Mariann Berhes, Ferenc Kiss, Endre Hajdu, Adam Deak, Abel Molnar, Judit Szabo, Bela Fulesdi

Research output: Contribution to journalArticle

13 Citations (Scopus)


The pathophysiology of hemorheological and microcirculatory disturbances in septic process -mostly during the early hours- still not clarified in all the details, yet. In anesthetized pigs living E. coli (ATCC 25922 strain) was administered intravenously with an increasing concentration and the animals were observed for 8 hours. Before the intervention and in every 2 hours arterial (cannulated femoral artery) and venous (cannulated external jugular vein) blood samples were collected for hemorheological laboratory tests: blood and plasma viscosity, ESR, leukocyte anti-sedimentation rate, erythrocyte deformability (together with osmoscan parameters) and erythrocyte aggregation (using light-transmission and laser back-scattering methods) Control animals were stable over the 8-hour anesthesia, while septic animals died by the 6th hours in a fulminant sepsis. Over the experimental period, the tendency of impairment in erythrocyte deformability (together with osmotic gradient ektacytometry parameters) and the controversial decreasing of erythrocyte aggregation values (declining all aggregation index values, elongating t1/2) were well detected in this porcine model during the early hours (4'6) of fulminant sepsis. The in vitro effect of these bacteria on erythrocytes' micro-rheological parameter was similar: decreasing red blood cell deformability and lowering aggregation. Further studies are needed to clarify the early micro-rheological changes of bacteremia and the developing sepsis.

Original languageEnglish
Pages (from-to)479-496
Number of pages18
JournalClinical hemorheology and microcirculation
Issue number3
Publication statusPublished - Jan 4 2016


  • Animal model
  • E. coli
  • Red blood cell aggregation
  • Red blood cell deformability
  • Sepsis

ASJC Scopus subject areas

  • Physiology
  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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