Early detection of metastasis by alterations in the cellular immune system in the murine liver and blood

N. Freudenberg, P. Rahner, C. Darda, A. Kiss, G. Verès, T. Nees, R. Lamers, U. N. Riede, C. Kortsik, M. Schubert, K. Frenzer-Welle

Research output: Contribution to journalArticle

Abstract

We investigated the reaction of the cellular immune system of liver and blood in the C57BL/6 mouse to a metastasizing Lewis lung carcinoma. The cellular immune system of the liver consists of mature and immature macrophages, B-cells, T-cells including their subpopulations, and natural killer cells, and their percentage frequencies differ significantly from those in the corresponding mononuclear blood cell (MBC) compartment. This suggests that the hepatic immune cells represent a system with autonomous function showing a typical homing of its members. Imminent metastasis to the liver is signalled by impressive alterations in the percentage frequencies of nonparenchymal liver cells (NPLC). There are a dramatic loss of mature macrophages, an increase in immature macrophages, a reduction of T-helper cells leading to a low CD4/CD8 ratio, and an increase in natural killer cells. In the blood, the corresponding precursor cells show comparable changes with a delay of at least 2 days. Early metastasis is accompanied by a significant increase in mononuclear NPLC producing tumour necrosis factor α. The alterations in percentage frequencies of the NPLC during tumour metastasis differ markedly from the changes in these cells in the liver during endotoxinaemia.

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalVirchows Archiv
Volume428
Issue number3
Publication statusPublished - 1996

Fingerprint

Immune System
Neoplasm Metastasis
Liver
Macrophages
Natural Killer Cells
Lewis Lung Carcinoma
CD4-CD8 Ratio
B-Lymphoid Precursor Cells
Helper-Inducer T-Lymphocytes
Inbred C57BL Mouse
Hepatocytes
Blood Cells
Tumor Necrosis Factor-alpha
T-Lymphocytes
Neoplasms

Keywords

  • Blood
  • Cellular immune system
  • Lewis lung carcinoma
  • Liver
  • Liver metastases
  • Tumour necrosis factor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Freudenberg, N., Rahner, P., Darda, C., Kiss, A., Verès, G., Nees, T., ... Frenzer-Welle, K. (1996). Early detection of metastasis by alterations in the cellular immune system in the murine liver and blood. Virchows Archiv, 428(3), 187-194.

Early detection of metastasis by alterations in the cellular immune system in the murine liver and blood. / Freudenberg, N.; Rahner, P.; Darda, C.; Kiss, A.; Verès, G.; Nees, T.; Lamers, R.; Riede, U. N.; Kortsik, C.; Schubert, M.; Frenzer-Welle, K.

In: Virchows Archiv, Vol. 428, No. 3, 1996, p. 187-194.

Research output: Contribution to journalArticle

Freudenberg, N, Rahner, P, Darda, C, Kiss, A, Verès, G, Nees, T, Lamers, R, Riede, UN, Kortsik, C, Schubert, M & Frenzer-Welle, K 1996, 'Early detection of metastasis by alterations in the cellular immune system in the murine liver and blood', Virchows Archiv, vol. 428, no. 3, pp. 187-194.
Freudenberg, N. ; Rahner, P. ; Darda, C. ; Kiss, A. ; Verès, G. ; Nees, T. ; Lamers, R. ; Riede, U. N. ; Kortsik, C. ; Schubert, M. ; Frenzer-Welle, K. / Early detection of metastasis by alterations in the cellular immune system in the murine liver and blood. In: Virchows Archiv. 1996 ; Vol. 428, No. 3. pp. 187-194.
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