A területen szerzett pneumonia korai és hosszú távú mortalitása

Translated title of the contribution: Early and late mortality of patients with community acquired pneumonia

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Community acquired pneumonia is the most frequent infective cause of severe sepsis and death. The risk of mortality in community acquired pneumonia is predictable by the "pneumonia severity index" and various biomarkers (e.g., procalcitonin, troponin-I). Quantitative testing of pneumococcal load (DNA) in blood has also become possible recently. Early death due to acute myocardial infarction is more frequent among patients with previous community acquired pneumonia. The 1-year and the 5-6 year survival is shorter among these patients. Pro-inflammatory cytokines synthesized during community acquired pneumonia accelerate chronic inflammation ongoing in atherosclerotic plaques. The pro-thrombotic condition present in atherosclerosis is also potentiated by community acquired pneumonia. These pathophysiological mechanisms may explain the epidemiologic fact that community acquired pneumonia is an independent risk factor of cardiovascular mortality.

Original languageHungarian
Pages (from-to)884-890
Number of pages7
JournalOrvosi Hetilap
Volume153
Issue number23
DOIs
Publication statusPublished - Jun 1 2012

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Pneumonia
Mortality
Troponin I
Calcitonin
Atherosclerotic Plaques
Sepsis
Atherosclerosis
Biomarkers
Myocardial Infarction
Cytokines
Inflammation
Survival
DNA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A területen szerzett pneumonia korai és hosszú távú mortalitása. / Losonczy, G.

In: Orvosi Hetilap, Vol. 153, No. 23, 01.06.2012, p. 884-890.

Research output: Contribution to journalArticle

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