Early age-dependent growth impairment in chronic renal failure

Johan Karlberg, Franz Schaefer, Mascha Hennicke, Anne Margret Wingen, Sue Rigden, Otto Mehls, I. Rätch, K. Michelis, T. Kapogiannis, F. Jung, T. Lennert, S. Gellert, T. Tulassay, P. Sallay, T. Von Lilien, D. Michalk, M. A. Von Wendt-Göknur, K. E. Bonzel, R. Gusmano, E. VerrinaG. Offner, O. Mehls, A. M. Wingen, C. Fabian-Bach, A. Appiani, A. Bettinelli, J. Feber, G. Rizzoni, S. Picca, H. J. Stolpe, M. Wigger, J. Kist-van Holthe, E. Wolff, U. Berg, M. Fischbach, E. Dobos, E. Balzar, T. Neuhaus

Research output: Contribution to journalArticle

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Abstract

We report early linear growth in 73 children (51 boys, 22 girls) with early onset of chronic renal failure (CRF). The inclusion criteria was onset of CRF before 6 months of age, two or more height measurements during the 1st year of life, follow-up for at least 3 years and continuously impaired renal function with a glomerular filtration rate below 50 ml/min per 1.73 m2 at 1 year or later. Only height measurements taken during conservative treatment or dialysis were included. The data were analysed in terms of the infancy-childhood-puberty growth model. There was an age-dependent growth failure in early life leading to an attained height of -3 standard deviation score (SDS) at 3 years of age. Approximately one-third of the reduction in height occurred during fetal life and one-third during the first postnatal months. Between 0.75 and 1.5 years of age height also decreased by 1 SD as a consequence of a delayed onset of the second, the 'childhood', phase of growth in 36% of the patients and by an 'offset childhood' growth pattern - i.e. a return to the infancy phase pattern after onset of the childhood phase - in 60% of the patients. Growth between 0.25-0.75 and 1.5-5 years of age was generally percentile parallel and thus less likely to be affected in CRF with early disease onset. The glomerular filtration rate was not related to the height gain in early life. We speculate that the growth failure during fetal life and the first postnatal months reflects metabolic and/or nutritional influences and the impaired growth at 0.75-1.5 years of age is related to a partial insensitivity to growth hormone.

Original languageEnglish
Pages (from-to)283-287
Number of pages5
JournalPediatric Nephrology
Volume10
Issue number3
DOIs
Publication statusPublished - Jun 1996

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Chronic Kidney Failure
Growth
Glomerular Filtration Rate
Puberty
Dialysis
Kidney

Keywords

  • Chronic renal failure
  • Growth hormone insensitivity
  • Height
  • Kidney disease
  • Longitudinal growth

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Karlberg, J., Schaefer, F., Hennicke, M., Wingen, A. M., Rigden, S., Mehls, O., ... Neuhaus, T. (1996). Early age-dependent growth impairment in chronic renal failure. Pediatric Nephrology, 10(3), 283-287. https://doi.org/10.1007/s004670050110

Early age-dependent growth impairment in chronic renal failure. / Karlberg, Johan; Schaefer, Franz; Hennicke, Mascha; Wingen, Anne Margret; Rigden, Sue; Mehls, Otto; Rätch, I.; Michelis, K.; Kapogiannis, T.; Jung, F.; Lennert, T.; Gellert, S.; Tulassay, T.; Sallay, P.; Von Lilien, T.; Michalk, D.; Von Wendt-Göknur, M. A.; Bonzel, K. E.; Gusmano, R.; Verrina, E.; Offner, G.; Mehls, O.; Wingen, A. M.; Fabian-Bach, C.; Appiani, A.; Bettinelli, A.; Feber, J.; Rizzoni, G.; Picca, S.; Stolpe, H. J.; Wigger, M.; Kist-van Holthe, J.; Wolff, E.; Berg, U.; Fischbach, M.; Dobos, E.; Balzar, E.; Neuhaus, T.

In: Pediatric Nephrology, Vol. 10, No. 3, 06.1996, p. 283-287.

Research output: Contribution to journalArticle

Karlberg, J, Schaefer, F, Hennicke, M, Wingen, AM, Rigden, S, Mehls, O, Rätch, I, Michelis, K, Kapogiannis, T, Jung, F, Lennert, T, Gellert, S, Tulassay, T, Sallay, P, Von Lilien, T, Michalk, D, Von Wendt-Göknur, MA, Bonzel, KE, Gusmano, R, Verrina, E, Offner, G, Mehls, O, Wingen, AM, Fabian-Bach, C, Appiani, A, Bettinelli, A, Feber, J, Rizzoni, G, Picca, S, Stolpe, HJ, Wigger, M, Kist-van Holthe, J, Wolff, E, Berg, U, Fischbach, M, Dobos, E, Balzar, E & Neuhaus, T 1996, 'Early age-dependent growth impairment in chronic renal failure', Pediatric Nephrology, vol. 10, no. 3, pp. 283-287. https://doi.org/10.1007/s004670050110
Karlberg J, Schaefer F, Hennicke M, Wingen AM, Rigden S, Mehls O et al. Early age-dependent growth impairment in chronic renal failure. Pediatric Nephrology. 1996 Jun;10(3):283-287. https://doi.org/10.1007/s004670050110
Karlberg, Johan ; Schaefer, Franz ; Hennicke, Mascha ; Wingen, Anne Margret ; Rigden, Sue ; Mehls, Otto ; Rätch, I. ; Michelis, K. ; Kapogiannis, T. ; Jung, F. ; Lennert, T. ; Gellert, S. ; Tulassay, T. ; Sallay, P. ; Von Lilien, T. ; Michalk, D. ; Von Wendt-Göknur, M. A. ; Bonzel, K. E. ; Gusmano, R. ; Verrina, E. ; Offner, G. ; Mehls, O. ; Wingen, A. M. ; Fabian-Bach, C. ; Appiani, A. ; Bettinelli, A. ; Feber, J. ; Rizzoni, G. ; Picca, S. ; Stolpe, H. J. ; Wigger, M. ; Kist-van Holthe, J. ; Wolff, E. ; Berg, U. ; Fischbach, M. ; Dobos, E. ; Balzar, E. ; Neuhaus, T. / Early age-dependent growth impairment in chronic renal failure. In: Pediatric Nephrology. 1996 ; Vol. 10, No. 3. pp. 283-287.
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AU - Schaefer, Franz

AU - Hennicke, Mascha

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AU - Mehls, Otto

AU - Rätch, I.

AU - Michelis, K.

AU - Kapogiannis, T.

AU - Jung, F.

AU - Lennert, T.

AU - Gellert, S.

AU - Tulassay, T.

AU - Sallay, P.

AU - Von Lilien, T.

AU - Michalk, D.

AU - Von Wendt-Göknur, M. A.

AU - Bonzel, K. E.

AU - Gusmano, R.

AU - Verrina, E.

AU - Offner, G.

AU - Mehls, O.

AU - Wingen, A. M.

AU - Fabian-Bach, C.

AU - Appiani, A.

AU - Bettinelli, A.

AU - Feber, J.

AU - Rizzoni, G.

AU - Picca, S.

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AU - Wigger, M.

AU - Kist-van Holthe, J.

AU - Wolff, E.

AU - Berg, U.

AU - Fischbach, M.

AU - Dobos, E.

AU - Balzar, E.

AU - Neuhaus, T.

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N2 - We report early linear growth in 73 children (51 boys, 22 girls) with early onset of chronic renal failure (CRF). The inclusion criteria was onset of CRF before 6 months of age, two or more height measurements during the 1st year of life, follow-up for at least 3 years and continuously impaired renal function with a glomerular filtration rate below 50 ml/min per 1.73 m2 at 1 year or later. Only height measurements taken during conservative treatment or dialysis were included. The data were analysed in terms of the infancy-childhood-puberty growth model. There was an age-dependent growth failure in early life leading to an attained height of -3 standard deviation score (SDS) at 3 years of age. Approximately one-third of the reduction in height occurred during fetal life and one-third during the first postnatal months. Between 0.75 and 1.5 years of age height also decreased by 1 SD as a consequence of a delayed onset of the second, the 'childhood', phase of growth in 36% of the patients and by an 'offset childhood' growth pattern - i.e. a return to the infancy phase pattern after onset of the childhood phase - in 60% of the patients. Growth between 0.25-0.75 and 1.5-5 years of age was generally percentile parallel and thus less likely to be affected in CRF with early disease onset. The glomerular filtration rate was not related to the height gain in early life. We speculate that the growth failure during fetal life and the first postnatal months reflects metabolic and/or nutritional influences and the impaired growth at 0.75-1.5 years of age is related to a partial insensitivity to growth hormone.

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