E. coli endotoxin shock in the cat: treatment with indomethacin

J. Parratt, R. M. Sturgess

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

An earlier study had demonstrated that indomethacin, administered before E. coli endotoxin, abolished the initial pulmonary vasoconstriction and delayed the onset of the secondary shock phase that results from the intravenous injection of this agent in cats. The object of the present study was to determine whether indomethacin modified the shock phase when administered after endotoxin. All the cats (whether or not they received indomethacin, 10 mg/kg) exhibited the characteristic features of the delayed shock phase that result from the administration of endotoxin (2 mg/kg). These included systemic hypotension, hypoglycaemia, reductions in arterial pH, cardiac output and systolic ejection time and an increase in arterial lactate. Five out of the ten animals given indomethacin survived 4 h compared with four out of twelve in the control (endotoxin alone) group. These results do not support the suggestion that antipyretic analgesic drugs like indomethacin may be of benefit when given during bacteraemic or septic shock. They do support the suggestion that the acute pulmonary changes (hypertension and decreased compliance) that occur in this species within a few minutes of endotoxin administration ultimately contribute to the severity of the shock phase.

Original languageEnglish
Pages (from-to)485-488
Number of pages4
JournalBritish Journal of Pharmacology
Volume53
Issue number4
Publication statusPublished - 1975

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Endotoxins
Indomethacin
Shock
Cats
Escherichia coli
Therapeutics
Antipyretics
Septic Shock
Vasoconstriction
Hypoglycemia
Pulmonary Hypertension
Intravenous Injections
Cardiac Output
Hypotension
Compliance
Analgesics
Lactic Acid
Lung

ASJC Scopus subject areas

  • Pharmacology

Cite this

E. coli endotoxin shock in the cat : treatment with indomethacin. / Parratt, J.; Sturgess, R. M.

In: British Journal of Pharmacology, Vol. 53, No. 4, 1975, p. 485-488.

Research output: Contribution to journalArticle

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