(E)-2-Benzylidenecyclanones: part XIV. Study on interaction of some (E)-2-benzylidenebenzosuberone derivatives with calf thymus DNA by TLC and UV–Vis methods, a DNA cleavage study

Zsuzsanna Rozmer, Evelin Marton, P. Perjési

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Interaction of some cyclic chalcone analogs, (E)-2-(4′-X-benzylidene)-1-benzosuberone derivatives, with calf thymus DNA has been investigated using thin-layer chromatographic and UV–Vis spectroscopic methods. Interaction of the compounds with calf thymus DNA exhibited relatively high intrinsic binding constants in the range of 3.1 × 104–1.0 × 105 M−1. The results indicate existence of weak, non-covalent interactions between the investigated chalcones with calf thymus DNA. Furthermore, the DNA cleavage activity of the compounds was studied by means of agarose gel electrophoresis. Each compound showed a slight DNA cleavage activity with pBR322. The obtained results provide additional knowledge on the previously documented cytotoxicity against several tumor cell lines of the cyclic chalcone analogs.

Original languageEnglish
Pages (from-to)2172-2179
Number of pages8
JournalMedicinal Chemistry Research
Volume26
Issue number9
DOIs
Publication statusPublished - Sep 1 2017

Keywords

  • Chalcones
  • DNA binding
  • DNA cleavage
  • Enones
  • UV/Vis spectroscopy

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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