Dystrophin splice variants are distinctly localized in the hippocampus

Diana Hazai, K. Halasy, D. Mornet, F. Hajós, Veronika Jancsik

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

It has previously been demonstrated that Dp71, the most abundant dystrophin protein in the brain, is mainly localized in the postsynaptic densities. Here we show the localization of Dp71f, one of the splice variants of this protein, within the CA3 region of the hippocampus. Immunopositivity occurs in the postsynaptic density of small asymmetrical axospinous and axodendritic synapses, while it is absent in the postsynaptic densities of the axospinous synapses of the large mossy fiber terminals. Dp71f immunoreactivity was found to be attached to the membranes of the mossy fibers in the stratum lucidum of the CA3 area. In a certain population of thin myelinated axons the protein seems to be present within the axon proper. These data support the notion of a physiological role of Dp71f distinct from other dystrophin isoforms present in the central nervous system.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalActa Biologica Hungarica
Volume57
Issue number2
DOIs
Publication statusPublished - 2006

Fingerprint

dystrophin
Post-Synaptic Density
Dystrophin
hippocampus
Hippocampus
Protein Isoforms
synapse
axons
Synapses
protein
Axons
Fibers
Neurology
Hippocampal CA3 Region
Brain
Proteins
proteins
nervous system
Membranes
central nervous system

Keywords

  • Dp71
  • Mossy fiber
  • Postsynaptic density

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Dystrophin splice variants are distinctly localized in the hippocampus. / Hazai, Diana; Halasy, K.; Mornet, D.; Hajós, F.; Jancsik, Veronika.

In: Acta Biologica Hungarica, Vol. 57, No. 2, 2006, p. 141-146.

Research output: Contribution to journalArticle

Hazai, Diana ; Halasy, K. ; Mornet, D. ; Hajós, F. ; Jancsik, Veronika. / Dystrophin splice variants are distinctly localized in the hippocampus. In: Acta Biologica Hungarica. 2006 ; Vol. 57, No. 2. pp. 141-146.
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