Dysregulation of microRNA Expression in Human Cervical Preneoplastic and Neoplastic Lesions

Ádám Galamb, Márta Benczik, Balázs Zinner, Eszter Vígh, Kornélia Baghy, Csaba Jeney, András Kiss, Gábor Lendvai, Gábor Sobel

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9 Citations (Scopus)

Abstract

Data discussed in recent reviews demonstrated that dysregulation of microRNA (miRNA) expression profiles occurs during cervical carcinogenesis and characteristic up- or downregulation of certain miRNAs might be used as biomarkers. The majority of altered miRNAs, however were found to be inconsistent upon comparison with cancerous and normal cervical epithelia in the discussed studies due to several reasons. The results obtained in this present review suggest the need for further investigations on miRNAs on larger sample sizes in order to indicate sensitivity and specificity by means of well defined, “unified” methods. In addition, obtaining further data on the clinical course and outcome of patients in comparison to the dysregulation of miRNA expression profile could turn miRNAs into prognostic and/or progression markers. Inhibition of overexpressed miRNAs, as suggested by some authors, might even serve as target for cancer therapy.

Original languageEnglish
Pages (from-to)503-508
Number of pages6
JournalPathology and Oncology Research
Volume21
Issue number3
DOIs
Publication statusPublished - Jul 5 2015

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Keywords

  • Biomarker
  • Cervical cancer
  • Cervix
  • Screening
  • microRNA

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this

Galamb, Á., Benczik, M., Zinner, B., Vígh, E., Baghy, K., Jeney, C., Kiss, A., Lendvai, G., & Sobel, G. (2015). Dysregulation of microRNA Expression in Human Cervical Preneoplastic and Neoplastic Lesions. Pathology and Oncology Research, 21(3), 503-508. https://doi.org/10.1007/s12253-014-9871-x