Dysbiotic gut microbiome: A key element of Crohn's disease

Styrk Furnes Øyri, G. Müzes, F. Sípos

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Since the first publication on "regional ileitis", the relevance of this chronic inflammatory disease condition termed finally as Crohn's disease is continuously increasing. Although we are beginning to comprehend certain aspects of its pathogenesis, many facets remain unexplored. Host's gut microbiota is involved in a wide range of physiological and pathological processes including immune system development, and pathogen regulation. Further, the microbiome is thought to play a key role in Crohn's disease. The presence of Crohn's-associated variants of NOD2 and ATG16L genes appears to be associated not only with alterations of mucosal barrier functions, and bacterial killing, but the gut microbiota, as well, reflecting a potential relationship between the host's genotype and intestinal dysbiosis, involved in disease etiology. This review aims to characterize some exciting new aspect of Crohn's disease pathology, focusing mainly on the role of intestinal microbes, and their interplay with the immune system of the host.

Original languageEnglish
Pages (from-to)36-49
Number of pages14
JournalComparative Immunology, Microbiology and Infectious Diseases
Volume43
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Crohn disease
Crohn Disease
digestive system
intestinal microorganisms
immune system
Immune System
Dysbiosis
Physiological Phenomena
etiology
Microbiota
Pathologic Processes
pathogenesis
microorganisms
Publications
Chronic Disease
pathogens
genotype
Genotype
Pathology
microbiome

Keywords

  • Crohn's disease
  • Dysbiosis
  • Gut microbiome
  • Immune system
  • Pathogenesis
  • Therapeutic aspects

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Infectious Diseases
  • Immunology and Allergy
  • veterinary(all)

Cite this

Dysbiotic gut microbiome : A key element of Crohn's disease. / Øyri, Styrk Furnes; Müzes, G.; Sípos, F.

In: Comparative Immunology, Microbiology and Infectious Diseases, Vol. 43, 01.12.2015, p. 36-49.

Research output: Contribution to journalArticle

@article{d4a366c374304db6be1bd8a5c8b1357c,
title = "Dysbiotic gut microbiome: A key element of Crohn's disease",
abstract = "Since the first publication on {"}regional ileitis{"}, the relevance of this chronic inflammatory disease condition termed finally as Crohn's disease is continuously increasing. Although we are beginning to comprehend certain aspects of its pathogenesis, many facets remain unexplored. Host's gut microbiota is involved in a wide range of physiological and pathological processes including immune system development, and pathogen regulation. Further, the microbiome is thought to play a key role in Crohn's disease. The presence of Crohn's-associated variants of NOD2 and ATG16L genes appears to be associated not only with alterations of mucosal barrier functions, and bacterial killing, but the gut microbiota, as well, reflecting a potential relationship between the host's genotype and intestinal dysbiosis, involved in disease etiology. This review aims to characterize some exciting new aspect of Crohn's disease pathology, focusing mainly on the role of intestinal microbes, and their interplay with the immune system of the host.",
keywords = "Crohn's disease, Dysbiosis, Gut microbiome, Immune system, Pathogenesis, Therapeutic aspects",
author = "{\O}yri, {Styrk Furnes} and G. M{\"u}zes and F. S{\'i}pos",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.cimid.2015.10.005",
language = "English",
volume = "43",
pages = "36--49",
journal = "Comparative Immunology, Microbiology and Infectious Diseases",
issn = "0147-9571",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Dysbiotic gut microbiome

T2 - A key element of Crohn's disease

AU - Øyri, Styrk Furnes

AU - Müzes, G.

AU - Sípos, F.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Since the first publication on "regional ileitis", the relevance of this chronic inflammatory disease condition termed finally as Crohn's disease is continuously increasing. Although we are beginning to comprehend certain aspects of its pathogenesis, many facets remain unexplored. Host's gut microbiota is involved in a wide range of physiological and pathological processes including immune system development, and pathogen regulation. Further, the microbiome is thought to play a key role in Crohn's disease. The presence of Crohn's-associated variants of NOD2 and ATG16L genes appears to be associated not only with alterations of mucosal barrier functions, and bacterial killing, but the gut microbiota, as well, reflecting a potential relationship between the host's genotype and intestinal dysbiosis, involved in disease etiology. This review aims to characterize some exciting new aspect of Crohn's disease pathology, focusing mainly on the role of intestinal microbes, and their interplay with the immune system of the host.

AB - Since the first publication on "regional ileitis", the relevance of this chronic inflammatory disease condition termed finally as Crohn's disease is continuously increasing. Although we are beginning to comprehend certain aspects of its pathogenesis, many facets remain unexplored. Host's gut microbiota is involved in a wide range of physiological and pathological processes including immune system development, and pathogen regulation. Further, the microbiome is thought to play a key role in Crohn's disease. The presence of Crohn's-associated variants of NOD2 and ATG16L genes appears to be associated not only with alterations of mucosal barrier functions, and bacterial killing, but the gut microbiota, as well, reflecting a potential relationship between the host's genotype and intestinal dysbiosis, involved in disease etiology. This review aims to characterize some exciting new aspect of Crohn's disease pathology, focusing mainly on the role of intestinal microbes, and their interplay with the immune system of the host.

KW - Crohn's disease

KW - Dysbiosis

KW - Gut microbiome

KW - Immune system

KW - Pathogenesis

KW - Therapeutic aspects

UR - http://www.scopus.com/inward/record.url?scp=84949818660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949818660&partnerID=8YFLogxK

U2 - 10.1016/j.cimid.2015.10.005

DO - 10.1016/j.cimid.2015.10.005

M3 - Article

C2 - 26616659

AN - SCOPUS:84949818660

VL - 43

SP - 36

EP - 49

JO - Comparative Immunology, Microbiology and Infectious Diseases

JF - Comparative Immunology, Microbiology and Infectious Diseases

SN - 0147-9571

ER -