Dysbiosis in Parkinson's disease might be triggered by certain antibiotics

Gábor Ternák, Dániel Kuti, Krisztina J. Kovács

Research output: Contribution to journalArticle

Abstract

Parkinson's disease (PD) is a neurodegenerative amyloid disorder with debilitating motor symptoms due to the loss of dopamine-synthesizing, basal ganglia-projecting neurons in the substantia nigra. An interesting feature of the disease is that most of PD patients have gastrointestinal problems and bacterial dysbiosis, years before the full expression of motor symptoms. We hypothesized that antibiotic consumption might be a contributing factor of gut microbiome dysbiosis in PD, favoring curli-producing Enterobacteria. Curli is a bacterial α-synuclein (αSyn) which is deposited first in the enteric nervous system and amyloid deposits are propagated in a prion like manner to the central nervous system. In addition, antibiotics result in a low-grade systemic inflammation, which also contributes to damage of neurons in enteric- and central nervous system. To support our hypothesis, by comparing PD prevalence change with antibiotic consumption data in EU countries, we found significant positive correlation between use narrow spectrum penicillin + penicillinase resistant penicillin and increased prevalence of the disease.

Original languageEnglish
Article number109564
JournalMedical Hypotheses
Volume137
DOIs
Publication statusPublished - Apr 2020

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Keywords

  • Amyloid-like protein
  • Antibiotics
  • Broad spectrum antibiotics
  • Curli protein
  • Dysbiosis
  • Microbiome
  • Narrow-spectrum penicillin
  • Parkinson's disease (PD)

ASJC Scopus subject areas

  • Medicine(all)

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