Dynamics of 125I-labelled horse serum albumin presentation in vivo inguinea pigs

Judit Pongracz, B. Csaba

Research output: Contribution to journalArticle

Abstract

Low antibody production in guinea-pig sera was determined by passive hemagglutination after 125I-labelled horse serum albumin (HoSA) injection. The appearance of radiolabelled HoSA on T cells, B cells and monocytes/macrophages (Mo) of guinea pigs was detected and followed as a function of time. The radio-activity peaks appeared first on Bcells and Mo, later on the T cells. The circulating T lymphocytes contained labelled antigen 7 days after the injection while T and B lymphocytes in the spleen preserved their radiioactivity 15 and 20 days later. Helper, suppressor and effector T cells were able to fix 125I-HoSA, this was shown by autoradiography using monoclonal antibodies 4 daysfollowing the antigen injection.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalInternational archives of allergy and immunology
Volume96
Issue number3
DOIs
Publication statusPublished - Jan 1 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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