Dynamic physical interactions of plasma membrane molecules generate cell surface patterns and regulate cell activation processes

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Molecular interaction and transmembrane signal transducing events generate a very dynamic and ever changing > in the plasma membranes. Lymphocytes, the key functional elements of the immune system, are eminently suited to be the primary targets to investigate these proximity, mobility, or other physical-chemical changes in their plasma membranes. Recently, a number of experiments suggested that processed peptides from antigens can bind specific components of MHC molecules (ELLIOT et al., 1991). This is certainly a way to alter their structure. Cell surface patterns of topological nature, assembly and disassembly of oligomeric receptor structure like the IL-2 receptor have been investigated by sophisticated biophysical techniques. The dynamic changes in the two-dimensional cell surface pattern and intramolecular conformational changes within this > macro-pattern may have a strong regulatory role in signal transducing and intercellular recognition processes. Recent data on these problems are presented together with brief and critical discussions.

Original languageEnglish
Pages (from-to)337-349
Number of pages13
JournalImmunobiology
Volume185
Issue number2-4
Publication statusPublished - 1992

Fingerprint

Cell Membrane
Interleukin-2 Receptors
Immune System
Lymphocytes
Antigens
Peptides

ASJC Scopus subject areas

  • Immunology

Cite this

@article{1465807997434882abb6263312476df1,
title = "Dynamic physical interactions of plasma membrane molecules generate cell surface patterns and regulate cell activation processes",
abstract = "Molecular interaction and transmembrane signal transducing events generate a very dynamic and ever changing > in the plasma membranes. Lymphocytes, the key functional elements of the immune system, are eminently suited to be the primary targets to investigate these proximity, mobility, or other physical-chemical changes in their plasma membranes. Recently, a number of experiments suggested that processed peptides from antigens can bind specific components of MHC molecules (ELLIOT et al., 1991). This is certainly a way to alter their structure. Cell surface patterns of topological nature, assembly and disassembly of oligomeric receptor structure like the IL-2 receptor have been investigated by sophisticated biophysical techniques. The dynamic changes in the two-dimensional cell surface pattern and intramolecular conformational changes within this > macro-pattern may have a strong regulatory role in signal transducing and intercellular recognition processes. Recent data on these problems are presented together with brief and critical discussions.",
author = "S. Damjanovich and L. M{\'a}tyus and M. Bal{\'a}zs and R. G{\'a}sp{\'a}r and Z. Krasznai and C. Pieri and J. Sz{\"o}llősi and L. Tr{\'o}n",
year = "1992",
language = "English",
volume = "185",
pages = "337--349",
journal = "Immunobiology",
issn = "0171-2985",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",
number = "2-4",

}

TY - JOUR

T1 - Dynamic physical interactions of plasma membrane molecules generate cell surface patterns and regulate cell activation processes

AU - Damjanovich, S.

AU - Mátyus, L.

AU - Balázs, M.

AU - Gáspár, R.

AU - Krasznai, Z.

AU - Pieri, C.

AU - Szöllősi, J.

AU - Trón, L.

PY - 1992

Y1 - 1992

N2 - Molecular interaction and transmembrane signal transducing events generate a very dynamic and ever changing > in the plasma membranes. Lymphocytes, the key functional elements of the immune system, are eminently suited to be the primary targets to investigate these proximity, mobility, or other physical-chemical changes in their plasma membranes. Recently, a number of experiments suggested that processed peptides from antigens can bind specific components of MHC molecules (ELLIOT et al., 1991). This is certainly a way to alter their structure. Cell surface patterns of topological nature, assembly and disassembly of oligomeric receptor structure like the IL-2 receptor have been investigated by sophisticated biophysical techniques. The dynamic changes in the two-dimensional cell surface pattern and intramolecular conformational changes within this > macro-pattern may have a strong regulatory role in signal transducing and intercellular recognition processes. Recent data on these problems are presented together with brief and critical discussions.

AB - Molecular interaction and transmembrane signal transducing events generate a very dynamic and ever changing > in the plasma membranes. Lymphocytes, the key functional elements of the immune system, are eminently suited to be the primary targets to investigate these proximity, mobility, or other physical-chemical changes in their plasma membranes. Recently, a number of experiments suggested that processed peptides from antigens can bind specific components of MHC molecules (ELLIOT et al., 1991). This is certainly a way to alter their structure. Cell surface patterns of topological nature, assembly and disassembly of oligomeric receptor structure like the IL-2 receptor have been investigated by sophisticated biophysical techniques. The dynamic changes in the two-dimensional cell surface pattern and intramolecular conformational changes within this > macro-pattern may have a strong regulatory role in signal transducing and intercellular recognition processes. Recent data on these problems are presented together with brief and critical discussions.

UR - http://www.scopus.com/inward/record.url?scp=0026756783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026756783&partnerID=8YFLogxK

M3 - Article

C2 - 1452209

AN - SCOPUS:0026756783

VL - 185

SP - 337

EP - 349

JO - Immunobiology

JF - Immunobiology

SN - 0171-2985

IS - 2-4

ER -