Dynamic interplay between metabolic syndrome and immunity

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

Obesity and its co-morbidities as metabolic syndrome, type 2 diabetes mellitus and cardiovascular diseases are major health problems worldwide. Several reports indicated that nutrient excess and metabolic syndrome are linked with altered immune response. Indeed, metabolic syndrome is characterized by insulin resistance and chronic low-grade inflammation, which conditions are the consequences of the complex interaction between adipocytes and immune cells. Enlarged white adipose tissue is infiltrated by immune cells and secretes various bioactive substances, like adipokines, cytokines and other inflammatory mediators. Due to its special architecture in which metabolic and immune cells are in intimate proximity, metabolic and immunologic pathways are closely integrated in adipose tissue. With the contribution of altered gut microbiota, adipokines and cytokines modulate insulin signaling and immune response leading to adipose tissue inflammation and systemic insulin resistance. In this chapter, we focus on the cellular and molecular mechanisms that lead to impaired insulin sensitivity and chronic low-grade inflammation in obesity. We also detail the potential role of adipokines and immune cells in this deleterious process, and the concerns of vaccination in metabolic syndrome. Finally, we address the links between obesity and gut microbiota as an emerging new field of interest, and scratch the surface of potential therapeutic opportunities.

Original languageEnglish
Title of host publicationOxidative Stress and Inflammation in Non-Communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
PublisherSpringer New York LLC
Pages171-190
Number of pages20
ISBN (Print)9783319073194
DOIs
Publication statusPublished - Jan 1 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume824
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Keywords

  • Adipokines
  • Gut microbiota
  • Immunity
  • Metabolic syndrome
  • Obesity
  • Obesity therapy
  • Vaccination

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Paragh, G., Seres, I., Harangi, M., & Fülöp, P. (2014). Dynamic interplay between metabolic syndrome and immunity. In Oxidative Stress and Inflammation in Non-Communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics (pp. 171-190). (Advances in Experimental Medicine and Biology; Vol. 824). Springer New York LLC. https://doi.org/10.1007/978-3-319-07320-0_13