Dynamic interplay between metabolic syndrome and immunity

G. Paragh, I. Seres, M. Harangi, Péter Fülöp

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Obesity and its co-morbidities as metabolic syndrome, type 2 diabetes mellitus and cardiovascular diseases are major health problems worldwide. Several reports indicated that nutrient excess and metabolic syndrome are linked with altered immune response. Indeed, metabolic syndrome is characterized by insulin resistance and chronic low-grade inflammation, which conditions are the consequences of the complex interaction between adipocytes and immune cells. Enlarged white adipose tissue is infiltrated by immune cells and secretes various bioactive substances, like adipokines, cytokines and other inflammatory mediators. Due to its special architecture in which metabolic and immune cells are in intimate proximity, metabolic and immunologic pathways are closely integrated in adipose tissue. With the contribution of altered gut microbiota, adipokines and cytokines modulate insulin signaling and immune response leading to adipose tissue inflammation and systemic insulin resistance. In this chapter, we focus on the cellular and molecular mechanisms that lead to impaired insulin sensitivity and chronic low-grade inflammation in obesity. We also detail the potential role of adipokines and immune cells in this deleterious process, and the concerns of vaccination in metabolic syndrome. Finally, we address the links between obesity and gut microbiota as an emerging new field of interest, and scratch the surface of potential therapeutic opportunities.

Original languageEnglish
Pages (from-to)171-190
Number of pages20
JournalAdvances in Experimental Medicine and Biology
Volume824
DOIs
Publication statusPublished - 2014

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Adipokines
Immunity
Insulin
Insulin Resistance
Obesity
Tissue
Medical problems
Inflammation
Adipose Tissue
Cytokines
White Adipose Tissue
Metabolic Networks and Pathways
Adipocytes
Type 2 Diabetes Mellitus
Nutrients
Vaccination
Cardiovascular Diseases
Morbidity
Food
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dynamic interplay between metabolic syndrome and immunity. / Paragh, G.; Seres, I.; Harangi, M.; Fülöp, Péter.

In: Advances in Experimental Medicine and Biology, Vol. 824, 2014, p. 171-190.

Research output: Contribution to journalArticle

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