Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans

Z. Maglóczky, Kinga Tóth, Rita Karlócai, Sára Nagy, Loránd Erocombining Double Acute Accentss, S. Czirják, J. Vajda, G. Rásonyi, A. Kelemen, Vera Juhos, P. Halász, Ken Mackie, T. Freund

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The endocannabinoid system plays a central role in retrograde synaptic communication, and controls both glutamatergic and γ-aminobutyric acid (GABA)ergic transmission via type 1 cannabinoid (CB1) receptor. Both in sclerotic human hippocampi and in the chronic phase of pilocarpineinduced epilepsy in mice with sclerosis, CB1-receptor-positive interneuron somata were preserved both in the dentate gyrus and in the CA1 area, and the density of CB1-immunostained fibers increased considerably in the dentate molecular layer. This suggests that, although CB1 receptors are known to be reduced in density on glutamatergic axons, the CB1-receptor-expressing GABAergic axons sprout, or there is an increase of CB1-receptor levels on these fibers. The changes of CB1 immunostaining in association with the GABAergic inhibitory system appear to correlate with the severity of pyramidal cell loss in the CA1 subfield. These results confirmthe involvement of the endocannabinoid system associated with GABAergic transmission in human temporal lobe epilepsy (TLE), as well as in the chronic phase of the pilocarpine model in mice. Pharmacotherapy aimed at the modulation of endocannabinoidmediated retrograde synaptic signaling should take into account the opposite change in CB1-receptor expression observed on glutamatergic versus GABAergic axon terminals.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalEpilepsia
Volume51
Issue numberSUPPL. 3
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Cannabinoid Receptor CB1
Hippocampus
Endocannabinoids
Axons
Aminobutyrates
Pilocarpine
Temporal Lobe Epilepsy
Pyramidal Cells
Dentate Gyrus
Presynaptic Terminals
Carisoprodol
Sclerosis
Interneurons
Epilepsy
Communication
Drug Therapy

Keywords

  • CB1 receptor
  • Epilepsy
  • Human hippocampus
  • Pilocarpine model
  • Sprouting

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans. / Maglóczky, Z.; Tóth, Kinga; Karlócai, Rita; Nagy, Sára; Erocombining Double Acute Accentss, Loránd; Czirják, S.; Vajda, J.; Rásonyi, G.; Kelemen, A.; Juhos, Vera; Halász, P.; Mackie, Ken; Freund, T.

In: Epilepsia, Vol. 51, No. SUPPL. 3, 07.2010, p. 115-120.

Research output: Contribution to journalArticle

Maglóczky Z, Tóth K, Karlócai R, Nagy S, Erocombining Double Acute Accentss L, Czirják S et al. Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans. Epilepsia. 2010 Jul;51(SUPPL. 3):115-120. https://doi.org/10.1111/j.1528-1167.2010.02624.x
Maglóczky, Z. ; Tóth, Kinga ; Karlócai, Rita ; Nagy, Sára ; Erocombining Double Acute Accentss, Loránd ; Czirják, S. ; Vajda, J. ; Rásonyi, G. ; Kelemen, A. ; Juhos, Vera ; Halász, P. ; Mackie, Ken ; Freund, T. / Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans. In: Epilepsia. 2010 ; Vol. 51, No. SUPPL. 3. pp. 115-120.
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