Dynamic analysis and control of biochemical reaction networks

Irene Otero-Muras, Gábor Szederkényi, Katalin M. Hangos, Antonio A. Alonso

Research output: Contribution to journalArticle

13 Citations (Scopus)


In the present work, we combine the concepts and tools from Irreversible Thermodynamics and Control Theory in a contribution to unravel the origin of complex nonlinear behaviour in biochemical networks. Regarding cells as thermodynamic systems, we can consider dynamic evolution of intracellular processes in terms of the combined action of an endogenous entropy production and the entropy flux associated to chemicals passing through the control volume. Based on a generalized description of biochemical systems, a physically motivated storage function is constructed and used for stability analysis. In this way, the entropy flux of open systems can be meaningfully modified by efficient nonlinear control schemes capable of network stabilization, and irreversible thermodynamics provide us with the physical insight to further interpret the controlled response.

Original languageEnglish
Pages (from-to)999-1009
Number of pages11
JournalMathematics and Computers in Simulation
Issue number4
Publication statusPublished - Dec 15 2008


  • Biochemical reaction networks
  • Multiplicities
  • Passivity based control
  • Thermodynamics

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)
  • Numerical Analysis
  • Modelling and Simulation
  • Applied Mathematics

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