Dydrogesterone and the immunology of pregnancy

Raj Raghupathy, J. Szekeres-Barthó

Research output: Contribution to journalReview article

Abstract

Progesterone is indispensable for the maintenance of pregnancy, both via its endocrine effects and its role in creating a favorable immunological environment for the fetus. This review focuses on the immunological effects of progesterone. Progestogens have been shown to have very interesting effects on cytokine production and decidual natural killer (NK) cell activity. The orally-administered progestogen, dydrogesterone, has the ability to modulate cytokine production patterns in a manner that could be conducive to successful pregnancy. The adverse effects of progesterone deficiency and the beneficial effects of progesterone supplementation in pregnancy pathologies will be discussed.

Original languageEnglish
Pages (from-to)63-71
Number of pages9
JournalHormone Molecular Biology and Clinical Investigation
Volume27
Issue number2
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Dydrogesterone
Allergy and Immunology
Progesterone
Pregnancy
Progestins
Pregnancy Maintenance
Cytokines
Natural Killer Cells
Fetus
Pathology

Keywords

  • cytokines
  • dydrogesterone
  • progesterone
  • recurrent spontaneous miscarriage

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)
  • Molecular Biology
  • Endocrinology

Cite this

Dydrogesterone and the immunology of pregnancy. / Raghupathy, Raj; Szekeres-Barthó, J.

In: Hormone Molecular Biology and Clinical Investigation, Vol. 27, No. 2, 01.08.2016, p. 63-71.

Research output: Contribution to journalReview article

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