Abstract
Progesterone is indispensable for the maintenance of pregnancy, both via its endocrine effects and its role in creating a favorable immunological environment for the fetus. This review focuses on the immunological effects of progesterone. Progestogens have been shown to have very interesting effects on cytokine production and decidual natural killer (NK) cell activity. The orally-administered progestogen, dydrogesterone, has the ability to modulate cytokine production patterns in a manner that could be conducive to successful pregnancy. The adverse effects of progesterone deficiency and the beneficial effects of progesterone supplementation in pregnancy pathologies will be discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 63-71 |
| Number of pages | 9 |
| Journal | Hormone Molecular Biology and Clinical Investigation |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 1 2016 |
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Keywords
- cytokines
- dydrogesterone
- progesterone
- recurrent spontaneous miscarriage
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Medicine(all)
- Molecular Biology
- Endocrinology
Cite this
Dydrogesterone and the immunology of pregnancy. / Raghupathy, Raj; Szekeres-Barthó, J.
In: Hormone Molecular Biology and Clinical Investigation, Vol. 27, No. 2, 01.08.2016, p. 63-71.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Dydrogesterone and the immunology of pregnancy
AU - Raghupathy, Raj
AU - Szekeres-Barthó, J.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Progesterone is indispensable for the maintenance of pregnancy, both via its endocrine effects and its role in creating a favorable immunological environment for the fetus. This review focuses on the immunological effects of progesterone. Progestogens have been shown to have very interesting effects on cytokine production and decidual natural killer (NK) cell activity. The orally-administered progestogen, dydrogesterone, has the ability to modulate cytokine production patterns in a manner that could be conducive to successful pregnancy. The adverse effects of progesterone deficiency and the beneficial effects of progesterone supplementation in pregnancy pathologies will be discussed.
AB - Progesterone is indispensable for the maintenance of pregnancy, both via its endocrine effects and its role in creating a favorable immunological environment for the fetus. This review focuses on the immunological effects of progesterone. Progestogens have been shown to have very interesting effects on cytokine production and decidual natural killer (NK) cell activity. The orally-administered progestogen, dydrogesterone, has the ability to modulate cytokine production patterns in a manner that could be conducive to successful pregnancy. The adverse effects of progesterone deficiency and the beneficial effects of progesterone supplementation in pregnancy pathologies will be discussed.
KW - cytokines
KW - dydrogesterone
KW - progesterone
KW - recurrent spontaneous miscarriage
UR - http://www.scopus.com/inward/record.url?scp=84989166083&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84989166083&partnerID=8YFLogxK
U2 - 10.1515/hmbci-2015-0062
DO - 10.1515/hmbci-2015-0062
M3 - Review article
VL - 27
SP - 63
EP - 71
JO - Hormone Molecular Biology and Clinical Investigation
JF - Hormone Molecular Biology and Clinical Investigation
SN - 1868-1883
IS - 2
ER -