Dual role of glucocorticoids in suckling-induced prolactin secretion

K. M. Horváth, Z. Bánky, B. E. Tóth, G. M. Nagy, B. Halász

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The exact contribution of corticosteroids to the control of prolactin secretion in lactating rats is poorly understood. Therefore, the present studies were focused on the effect of adrenalectomy and dexamethasone treatment on the suckling-induced prolactin release. Animals were adrenalectomized on the 3rd day of lactation and tested on the 7th day of lactation. In adrenalectomized animals, the suckling stimulus failed to induce the characteristic increase in plasma prolactin levels. Dexamethasone pretreatment (400 μg/kg b.w. s.c. 24, 48, 72 h before testing) of adrenalectomized rats restored this prolactin response. The same treatment with dexamethasone given to control animals attenuated the suckling stimulus induced prolactin response. The present findings indicate that corticosteroids are essential for a basic prolactin response of lactating rats.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalEndocrine
Volume15
Issue number3
DOIs
Publication statusPublished - Jan 1 2001

Keywords

  • Adrenalectomy
  • Corticosteroids
  • Dexamethasone
  • Lactation
  • Prolactin
  • Suckling stimulus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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