Dual promoters and tissue-specific expression of rat transthyretin gene

Kiyoto Motojima, S. Goto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The rat chromosomal gene for transthyretin was cloned and its dual promoter region was analyzed by primer extension. Semi-quantitative studies by primer extension analysis to determine the transcriptional start sites and their usage in the three tissues have suggested that the rat transthyetin gene has dual promoters: a major proximal promoter which is used in the liver and in the brain but not at all in the kidney, and a minor distal promoter which is totally used in the kidney and significantly in the brain.

Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume173
Issue number1
DOIs
Publication statusPublished - Nov 30 1990

Fingerprint

Prealbumin
Rats
Brain
Genes
Tissue
Kidney
Genetic Promoter Regions
Liver

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Dual promoters and tissue-specific expression of rat transthyretin gene. / Motojima, Kiyoto; Goto, S.

In: Biochemical and Biophysical Research Communications, Vol. 173, No. 1, 30.11.1990, p. 323-330.

Research output: Contribution to journalArticle

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