Dual hydrogen-bond/enamine catalysis enables a direct enantioselective three-component domino reaction

Hasibur Rahaman, Údám Madarász, Imre Pápai, Petri M. Pihko

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

It takes two to tango: A dual catalyst system, composed of a highly enantioselective enamine catalyst and a multiple-hydrogen-bond catalyst, enabled the chemoselective union of two aldehydes and a nitromethane unit with near-perfect enantioselectivities, excellent diastereoselectivities, and high yields under neutral conditions (see scheme).

Original languageEnglish
Pages (from-to)6123-6127
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number27
DOIs
Publication statusPublished - Jun 27 2011

Keywords

  • domino reactions
  • enamine catalysis
  • hydrogen-bond catalysis
  • nitroolefins
  • organocatalysis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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