DSC studies on the polymorphism and pseudopolymorphism of pharmaceutical substances - A complex system for studying physico-chemical behaviour of binary mixtures

K. Marthi, M. Ács, G. Pokol, K. Tomor, K. Eröss-Kiss

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A complex system including thermoanalytical methods, infrared spectroscopy and X-ray powder diffraction for studying physico-chemical behaviour of binary mixtures is described. This system has been tested by investigating binary mixtures of amphetamine hydrochloride salts. These studies have proved that among the selected compounds the primary and secondary amine hydrochloride salts exhibit conglomerate forming tendency, while the tertiary amine hydrochloride salts form molecular compounds (racemates). For the p-fluoro amphetamine hydrochloride the existence of two polymorphic modifications has been detected.

Original languageEnglish
Pages (from-to)1017-1025
Number of pages9
JournalJournal of Thermal Analysis
Volume38
Issue number4
DOIs
Publication statusPublished - Apr 1992

Fingerprint

polymorphism
hydrochlorides
Binary mixtures
Polymorphism
complex systems
Drug products
binary mixtures
Large scale systems
amphetamines
Salts
Amphetamine
Amines
salts
Pharmaceutical Preparations
amines
X ray powder diffraction
Infrared spectroscopy
tendencies
infrared spectroscopy
diffraction

Keywords

  • pharmaceutical substances
  • polymorphism
  • pseudopolymorphism

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

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AU - Pokol, G.

AU - Tomor, K.

AU - Eröss-Kiss, K.

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