DSC examinations on cataractous lens materials obtained by phacoemulsification

Zs Biró, Vanda Nemes, G. A. Molnár, I. Wittmann, Andrea Ludány, D. Lorinczy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Modifications of lens proteins play a crucial role in the formation of cataract, which is among the leading causes of world blindness in the ageing population. Although modern cataract surgery by phacoemulsification is a very successful and safe procedure, the prevention of cataract formation would be a real breakthrough in this field of ophthalmology. The aim of our study was to analyse the thermal denaturation of the cataractous lens proteins by the method of differential scanning calorimetry (DSC), to understand cataract formation and to work on its prevention possibilities. Samples were obtained from cataract patients of different age, sex, patients with and without diabetes mellitus. Samples were obtained from lenses of mature degree and progredient degree of cataract as well. Previous DSC examinations were performed on manually extracted human cataractous lens materials, however to the best of our knowledge, this is the first study, in which DSC examinations were performed on lens materials obtained by the phacoemulsification technique, which gained acceptance world-wide in the last decade.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalJournal of Thermal Analysis and Calorimetry
Volume85
Issue number2
DOIs
Publication statusPublished - Aug 1 2006

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Keywords

  • Cataract
  • DSC
  • Diabetes
  • Phacoemulsification

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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