Drugs affecting brain dopamine interfere with the effect of Z-prolyl-D-leucine on morphine withdrawal

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4 Citations (Scopus)

Abstract

The dipeptide Z-prolyl-D-leucine (Z-Pro-D-Leu) has been demonstrated to inhibit the development of tolerance to and dependence on morphine in the mouse. Since the dipeptide affects dopamine (DA) utilization in the terminal regions of the mesolimbic and nigrostriatal DA-ergic projections, the question has been studied of whether DA-ergic mechanisms are involved in the action of Z-Pro-D-Leu on morphine withdrawal. Both inhibition of tyrosine hydroxylase by α-methyl-p-tyrosine (α-MPT) and inhibition of DA receptors by pimozide interfere with the effect of Z-Pro-D-Leu on naloxone-precipitated morphine withdrawal. Inhibition of serotonin (5-HT) synthesis by DL-p-chlorophenylalanine (PCPA), on the other hand, does not modify the effect of the dipeptide. The results argue for a role of DA-ergic mechanisms in the effect of Z-Pro-D-Leu on the development of morphine dependence.

Original languageEnglish
Pages (from-to)345-348
Number of pages4
JournalPharmacology Biochemistry and Behavior
Volume21
Issue number3
DOIs
Publication statusPublished - Jan 1 1984

Keywords

  • DA synthesis
  • Morphine withdrawal
  • Receptors
  • Z-Pro-D-Leu

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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