Drugs acting on calcium channels modulate the diuretic and micturition effects of dexmedetomidine in rats

Gyöngyi Horváth, Zita Morvay, Mónika Kovács, Annamária Szilágyi, Margit Szikszay

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The purpose of this study was to assess the effects of calcium channel antagonist, verapamil, and agonist, Bay K 8644, on the α2-adrenoceptor agonist, dexmedetomidine-induced (300 μg kg-1 subcutaneously) diuresis and overflow incontinence, in rats. Ultrasonography study revealed that verapamil (2.5 mg kg-1 subcutaneously) or Bay K 8644 (0.5 mg kg-1 intraperitoneally) coadministrations delayed dexmedetomidine-induced bladder filling and significantly prolonged the latency of urination (P-1) dose-dependently decreased the diuretic effect of dexmedetomidine (P-1) dose-dependently decreased urine volume in the first hour (P2-adrenoceptor agonists and calcium channel blockers have frequently been used for antihypertensive therapy and as adjuvant drugs during anesthesia, these interactions may have some practical importance.

Original languageEnglish
Pages (from-to)1247-1257
Number of pages11
JournalLife Sciences
Volume59
Issue number15
DOIs
Publication statusPublished - Sep 6 1996

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Dexmedetomidine
Urination
Calcium Channels
Diuretics
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
Rats
Calcium Channel Blockers
Verapamil
Adrenergic Receptors
Calcium Channel Agonists
Pharmaceutical Preparations
Ultrasonography
Diuresis
Adjuvant Chemotherapy
Antihypertensive Agents
Urinary Bladder
Anesthesia
Urine

Keywords

  • alpha adrenoceptor agonist
  • Bay K 8644
  • calcium channel agonist
  • dexmedetomidine
  • micturition
  • urinary bladder
  • verapamil

ASJC Scopus subject areas

  • Pharmacology

Cite this

Drugs acting on calcium channels modulate the diuretic and micturition effects of dexmedetomidine in rats. / Horváth, Gyöngyi; Morvay, Zita; Kovács, Mónika; Szilágyi, Annamária; Szikszay, Margit.

In: Life Sciences, Vol. 59, No. 15, 06.09.1996, p. 1247-1257.

Research output: Contribution to journalArticle

Horváth, Gyöngyi ; Morvay, Zita ; Kovács, Mónika ; Szilágyi, Annamária ; Szikszay, Margit. / Drugs acting on calcium channels modulate the diuretic and micturition effects of dexmedetomidine in rats. In: Life Sciences. 1996 ; Vol. 59, No. 15. pp. 1247-1257.
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