Drug treatment during pregnancy and isolated orofacial clefts in Hungary

E. Puhó, Melinda Szunyogh, J. Métneki, E. Czeizel

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Objective: To evaluate the possible association between all kinds of drug treatments during pregnancy and isolated cleft lip with or without cleft palate (CL/P) and posterior cleft palate (PCP) in the offspring. Setting: The dataset of the large population-based Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996, was evaluated. Participants: One thousand three hundred seventy-four cases with isolated CL/P and 601 with PCP, plus 38,151 population controls (without birth defects) and 20,868 malformed controls with other defects. Intervention: In this observation case-control study the data collection was based on prospective medical records particularly prenatal logbook, retrospective maternal data via a self-reported questionnaire, and home visits of nonresponding mothers. Main outcome measures: Isolated CL/P and PCP associated with drug treatments during pregnancy. Results: An increased risk for isolated CL/P was found in cases born to mothers treated with amoxicillin, phenytoin, oxprenolol, and thiethylperazine during the second and third month of pregnancy, i.e., the critical period of isolated CL/P. Risk of isolated PCP was increased in mothers with oxytetracycline and carbamazepine treatment during the third and fourth month of pregnancy, i.e., the critical period of PCP. Conclusions: This study confirmed the orofacial cleft (OFC) inducing effect of phenytoin, carbamazepine, oxytetracycline, and thiethylperazine and suggested a possible association between OFCs and oxprenolol and amoxicillin. However, drugs may have only a limited role in the origin of isolated OFCs.

Original languageEnglish
Pages (from-to)194-202
Number of pages9
JournalCleft Palate-Craniofacial Journal
Volume44
Issue number2
DOIs
Publication statusPublished - Mar 2007

Fingerprint

Hungary
Cleft Palate
Pregnancy
Pharmaceutical Preparations
Thiethylperazine
Oxprenolol
Oxytetracycline
Amoxicillin
Carbamazepine
Phenytoin
House Calls
Population Control
Cleft Lip
Medical Records
Case-Control Studies
Mothers
Outcome Assessment (Health Care)

Keywords

  • Amoxicillin
  • Carbamazepine
  • Case-control studies
  • Cleft lip
  • Cleft lip and palate
  • Oxprenolol
  • Oxytetracycline
  • Phenytoin
  • Posterior cleft palate
  • Pregnancy
  • Thiethylperazine

ASJC Scopus subject areas

  • Surgery
  • Dentistry(all)

Cite this

Drug treatment during pregnancy and isolated orofacial clefts in Hungary. / Puhó, E.; Szunyogh, Melinda; Métneki, J.; Czeizel, E.

In: Cleft Palate-Craniofacial Journal, Vol. 44, No. 2, 03.2007, p. 194-202.

Research output: Contribution to journalArticle

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abstract = "Objective: To evaluate the possible association between all kinds of drug treatments during pregnancy and isolated cleft lip with or without cleft palate (CL/P) and posterior cleft palate (PCP) in the offspring. Setting: The dataset of the large population-based Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996, was evaluated. Participants: One thousand three hundred seventy-four cases with isolated CL/P and 601 with PCP, plus 38,151 population controls (without birth defects) and 20,868 malformed controls with other defects. Intervention: In this observation case-control study the data collection was based on prospective medical records particularly prenatal logbook, retrospective maternal data via a self-reported questionnaire, and home visits of nonresponding mothers. Main outcome measures: Isolated CL/P and PCP associated with drug treatments during pregnancy. Results: An increased risk for isolated CL/P was found in cases born to mothers treated with amoxicillin, phenytoin, oxprenolol, and thiethylperazine during the second and third month of pregnancy, i.e., the critical period of isolated CL/P. Risk of isolated PCP was increased in mothers with oxytetracycline and carbamazepine treatment during the third and fourth month of pregnancy, i.e., the critical period of PCP. Conclusions: This study confirmed the orofacial cleft (OFC) inducing effect of phenytoin, carbamazepine, oxytetracycline, and thiethylperazine and suggested a possible association between OFCs and oxprenolol and amoxicillin. However, drugs may have only a limited role in the origin of isolated OFCs.",
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