Drug targets of migraine and neuropathy: Treatment of hyperexcitability

László Vécsei, Zsófia Majláth, Anna Balog, János Tajti

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Migraine and neuropathic pain are common causes of chronic pain. The exact pathomechanism has not been fully clarified for either disorder, but their pathophysiological backgrounds involve several similar mechanisms. Peripheral sensitization occurs in the neuronal elements of the dorsal root ganglion or the trigeminal ganglion, while central sensitization appears in the second-order neurons in the dorsal horn of the spinal cord or the trigeminal nucleus caudalis. Central neuronal hyperexcitability has been implicated in both disorders, and the emerging evidence suggests alterations in the glutamatergic neurotransmission and N-methyl-D-aspartate-receptor activation. Migraine and neuropathic pain additionally share certain clinical features, such as enhanced sensitivity to sensory stimuli and cutaneous allodynia. The pharmacotherapy of both diseases is often challenging, but several antiepileptic drugs that target hyperexcitability are beneficial for both migraine and neuropathic pain. Kynurenine pathway metabolites are capable of influencing the glutamate receptors, and might therefore be novel candidates for future drug development.

Original languageEnglish
Pages (from-to)664-676
Number of pages13
JournalCNS and Neurological Disorders - Drug Targets
Volume14
Issue number5
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Allodynia
  • Glutamate
  • Hyperexcitability
  • Migraine
  • Neuropathic pain
  • Sensitization

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

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