Drug release profiles and microstructural characterization of cast and freeze dried vitamin B12 buccal films by positron annihilation lifetime spectroscopy

Barnabás Szabó, Nikolett Kállai, Gergo Tóth, Gergely Hetényi, Romána Zelkó

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Solvent cast and freeze dried films, containing the water-soluble vitamin B12 as model drug were prepared from two polymers, sodium alginate (SA), and Carbopol 71G (CP). The proportion of the CP was changed in the films. The microstructural characterization of various samples was carried out by positron annihilation lifetime spectroscopy (PALS). The drug release kinetics of untreated and stored samples was evaluated by the conventionally applied semi-empirical power law.Correlation was found between the changes of the characteristic parameters of the drug release and the ortho-positronium (o-Ps) lifetime values of polymer samples. The results indicated that the increase of CP concentration, the freeze-drying process and the storage at 75% R.H. decreased the rate of drug release.The PALS method enabled the distinction between the micro- and macrostructural factors influencing the drug release profile of polymer films.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume89
DOIs
Publication statusPublished - Feb 15 2014

Keywords

  • Cast film
  • Dissolution
  • Freeze-drying
  • Positron annihilation lifetime spectroscopy (PALS)
  • Vitamin B

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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