Drug-induced hepatic injury is the most frequent reason cited for the withdrawal from the market. It is also accounts for more than 50 percent of the cases of acute liver failure in the United States. More than 75 percent of cases of idiosyncratic drug reactions results in liver transplantation or death. The annual incidence rate per 100.000 inhabitants of 13.9±2.4. Sgro et al. attempted to derive a more accurate assessment of drug-induced liver disease occurring over a 3-year period in France. 34 cases among 81.000 persons were diagnosed. The drugs implicated included a number of well-described hepatotoxins from the nonsteroidal antiinflammatory, psychotropic, antiinfectious and hypolipidemic drug classes. In the United Kingdom reviewed medications are most commonly associated with fatal adverse reactions in children aged 16 or fewer years. Hepatic failure was the most common cause of death. Antibiotics, anesthetics and anticonvulsant were the most frequent causes of death.
|Number of pages||5|
|Publication status||Published - Dec 1 2004|
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