Drug - Eluting stents promote late platelet-derived microvesicle release

Katarina Vargova, Éva Pállinger, Zsófia Horváth, Andrea Kovács, Sarolta Leé, Emese Tóth-Zsámboki, István Préda, Edit Buzás, Róbert Gábor Kiss

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Microvesicles (MVs) are membrane-derived microparticles originating from different cell types, commonly from platelets (PMVs). The aim of the study was to determine the PMV release after elective PCI. We recruited 98 stable angina (SAP) patients undergoing diagnostic coronary angiography (CA). PCI was performed in 37 patients with implantation of bare metal stents (BMS, n=14) or drug - eluting stents (DES, n=23). 34 SAP patients with significant coronary stenosis referred to CABG, or optimal medical treatment (NOPCI group) and 27 SAP patients with macroscopically normal coronary arteries (NC group) served as controls. Total MV count, CD41+ PMVs, P-selectin negative PMVs(CD62P-/CD41+PMV) and P-selectin positive PMVs(CD62P+/CD41+PMV) were determined by flow-cytometry upon admission, 24 hours, and 1, 3, 6, 12 months after PCI/ CA. 24 hours after PCI the total MV (p<0.05), CD41+PMV (p<0.01) and CD62P-/CD41+PMV (p<0.05) count significantly increased compared to baseline. Six month after DES implantation CD41+PMV (p<0.05) and CD62P-/CD41+PMV (p<0.05) count was significantly higher compared to BMS group. Significant PMV release was detected at 24 hours after PCI indicating PCI-related acute platelet response. DES implantation resulted in higher PMV counts compared to BMS at 6 months, representing late platelet activation signal.

Original languageEnglish
Pages (from-to)3713-3722
Number of pages10
JournalExperimental and Clinical Cardiology
Volume20
Issue number6
Publication statusPublished - 2014

Keywords

  • Angina pectoris
  • Blood platelets
  • Cell- Derived microparticles
  • Drug - Eluting stent
  • Percutaneous coronary intervention

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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