Drug - Eluting stents promote late platelet-derived microvesicle release

Katarina Vargova, E. Pállinger, Zsófia Horváth, Andrea Kovács, Sarolta Leé, E. Tóth-Zsámboki, I. Préda, E. Búzás, R. Kiss

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Microvesicles (MVs) are membrane-derived microparticles originating from different cell types, commonly from platelets (PMVs). The aim of the study was to determine the PMV release after elective PCI. We recruited 98 stable angina (SAP) patients undergoing diagnostic coronary angiography (CA). PCI was performed in 37 patients with implantation of bare metal stents (BMS, n=14) or drug - eluting stents (DES, n=23). 34 SAP patients with significant coronary stenosis referred to CABG, or optimal medical treatment (NOPCI group) and 27 SAP patients with macroscopically normal coronary arteries (NC group) served as controls. Total MV count, CD41+ PMVs, P-selectin negative PMVs(CD62P-/CD41+PMV) and P-selectin positive PMVs(CD62P+/CD41+PMV) were determined by flow-cytometry upon admission, 24 hours, and 1, 3, 6, 12 months after PCI/ CA. 24 hours after PCI the total MV (p

Original languageEnglish
Pages (from-to)3713-3722
Number of pages10
JournalExperimental and Clinical Cardiology
Volume20
Issue number6
Publication statusPublished - 2014

Fingerprint

Drug-Eluting Stents
Blood Platelets
P-Selectin
Coronary Angiography
Stable Angina
Coronary Stenosis
Stents
Coronary Vessels
Flow Cytometry
Metals
Membranes
Therapeutics

Keywords

  • Angina pectoris
  • Blood platelets
  • Cell- Derived microparticles
  • Drug - Eluting stent
  • Percutaneous coronary intervention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

Cite this

Drug - Eluting stents promote late platelet-derived microvesicle release. / Vargova, Katarina; Pállinger, E.; Horváth, Zsófia; Kovács, Andrea; Leé, Sarolta; Tóth-Zsámboki, E.; Préda, I.; Búzás, E.; Kiss, R.

In: Experimental and Clinical Cardiology, Vol. 20, No. 6, 2014, p. 3713-3722.

Research output: Contribution to journalArticle

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AU - Vargova, Katarina

AU - Pállinger, E.

AU - Horváth, Zsófia

AU - Kovács, Andrea

AU - Leé, Sarolta

AU - Tóth-Zsámboki, E.

AU - Préda, I.

AU - Búzás, E.

AU - Kiss, R.

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