Drug-eluting introducer sheath prevents local peripheral complications

Rayyan Hemetsberger, A. Pósa, Serdar Farhan, Hani Hemetsberger, Bassam Redwan, Noemi Pavo, Imre J. Pavo, Christian A. Plass, Örs Petnehazy, Zsolt Petrasi, Kurt Huber, Dietmar Glogar, Gerald Maurer, Mariann Gyngysi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives This study evaluated the protective effect of nitric oxidecoating of introducer sheath on the local complications in juvenile porcine femoral arteries with similar size to human radial arteries. Background Insertion of an introducer sheath induces vasospasm and transient or permanent vessel occlusion of radial arteries. Methods Nitric oxidecoated or control introducer sheaths with or without spasmolytic cocktail (control + C-sheath) were inserted into porcine femoral arteries, followed by percutaneous coronary intervention (PCI). The diameter of the femoral artery at the puncture site, distally and proximally, was measured by quantitative angiography. Histopathological and histomorphometric parameters of the femoral arteries were analyzed 1 h or 1 week after PCI. Results Insertion of femoral sheath led to mild or severe spasms, with significantly higher vessel diameter at the access site (2.69 ± 0.81 mm vs. 1.77 ± 0.77 mm and 1.85 ± 0.66 mm, p <0.001), and proximal and distal to it, during PCI in the nitric oxidesheath group versus the control-sheath and control + C-sheath groups, respectively. Immediately following PCI, significantly less luminal thrombosis (12% vs. 33% and 31% of all analyzed segments, p <0.001) was observed in the nitric oxidesheath arteries. At 1 week, lower intimal inflammation score (0.43 ± 11 vs. 1.03 ± 0.35 and 1.04 ± 0.32, p <0.05), less luminal thrombosis (8% vs. 21% and 30% p <0.05), and smaller intimal hyperplasia (0.31 ± 0.31 mm2 vs. 0.47 ± 1.00 mm 2 and 0.86 ± 0.82 mm2, p <0.05) were observed in NO-sheath arteries at the injury site. Conclusions Nitric oxide coating on the introducer sheath prevents local complications during PCI and results in less vascular thrombosis and inflammation at the access site, contributing to patency of the access vessel with similar size to the radial artery.

Original languageEnglish
Pages (from-to)98-106
Number of pages9
JournalJACC: Cardiovascular Interventions
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 2011

Fingerprint

Percutaneous Coronary Intervention
Femoral Artery
Radial Artery
Tunica Intima
Thrombosis
Pharmaceutical Preparations
Swine
Arteries
Inflammation
Parasympatholytics
Spasm
Thigh
Punctures
Hyperplasia
Blood Vessels
Angiography
Nitric Oxide
Control Groups
Wounds and Injuries

Keywords

  • drug-coating
  • introducer sheath
  • nitric oxide
  • percutaneous coronary intervention
  • radial artery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hemetsberger, R., Pósa, A., Farhan, S., Hemetsberger, H., Redwan, B., Pavo, N., ... Gyngysi, M. (2011). Drug-eluting introducer sheath prevents local peripheral complications. JACC: Cardiovascular Interventions, 4(1), 98-106. https://doi.org/10.1016/j.jcin.2010.09.018

Drug-eluting introducer sheath prevents local peripheral complications. / Hemetsberger, Rayyan; Pósa, A.; Farhan, Serdar; Hemetsberger, Hani; Redwan, Bassam; Pavo, Noemi; Pavo, Imre J.; Plass, Christian A.; Petnehazy, Örs; Petrasi, Zsolt; Huber, Kurt; Glogar, Dietmar; Maurer, Gerald; Gyngysi, Mariann.

In: JACC: Cardiovascular Interventions, Vol. 4, No. 1, 01.2011, p. 98-106.

Research output: Contribution to journalArticle

Hemetsberger, R, Pósa, A, Farhan, S, Hemetsberger, H, Redwan, B, Pavo, N, Pavo, IJ, Plass, CA, Petnehazy, Ö, Petrasi, Z, Huber, K, Glogar, D, Maurer, G & Gyngysi, M 2011, 'Drug-eluting introducer sheath prevents local peripheral complications', JACC: Cardiovascular Interventions, vol. 4, no. 1, pp. 98-106. https://doi.org/10.1016/j.jcin.2010.09.018
Hemetsberger, Rayyan ; Pósa, A. ; Farhan, Serdar ; Hemetsberger, Hani ; Redwan, Bassam ; Pavo, Noemi ; Pavo, Imre J. ; Plass, Christian A. ; Petnehazy, Örs ; Petrasi, Zsolt ; Huber, Kurt ; Glogar, Dietmar ; Maurer, Gerald ; Gyngysi, Mariann. / Drug-eluting introducer sheath prevents local peripheral complications. In: JACC: Cardiovascular Interventions. 2011 ; Vol. 4, No. 1. pp. 98-106.
@article{fc2d96de75f841598a24bdd141bbe8bb,
title = "Drug-eluting introducer sheath prevents local peripheral complications",
abstract = "Objectives This study evaluated the protective effect of nitric oxidecoating of introducer sheath on the local complications in juvenile porcine femoral arteries with similar size to human radial arteries. Background Insertion of an introducer sheath induces vasospasm and transient or permanent vessel occlusion of radial arteries. Methods Nitric oxidecoated or control introducer sheaths with or without spasmolytic cocktail (control + C-sheath) were inserted into porcine femoral arteries, followed by percutaneous coronary intervention (PCI). The diameter of the femoral artery at the puncture site, distally and proximally, was measured by quantitative angiography. Histopathological and histomorphometric parameters of the femoral arteries were analyzed 1 h or 1 week after PCI. Results Insertion of femoral sheath led to mild or severe spasms, with significantly higher vessel diameter at the access site (2.69 ± 0.81 mm vs. 1.77 ± 0.77 mm and 1.85 ± 0.66 mm, p <0.001), and proximal and distal to it, during PCI in the nitric oxidesheath group versus the control-sheath and control + C-sheath groups, respectively. Immediately following PCI, significantly less luminal thrombosis (12{\%} vs. 33{\%} and 31{\%} of all analyzed segments, p <0.001) was observed in the nitric oxidesheath arteries. At 1 week, lower intimal inflammation score (0.43 ± 11 vs. 1.03 ± 0.35 and 1.04 ± 0.32, p <0.05), less luminal thrombosis (8{\%} vs. 21{\%} and 30{\%} p <0.05), and smaller intimal hyperplasia (0.31 ± 0.31 mm2 vs. 0.47 ± 1.00 mm 2 and 0.86 ± 0.82 mm2, p <0.05) were observed in NO-sheath arteries at the injury site. Conclusions Nitric oxide coating on the introducer sheath prevents local complications during PCI and results in less vascular thrombosis and inflammation at the access site, contributing to patency of the access vessel with similar size to the radial artery.",
keywords = "drug-coating, introducer sheath, nitric oxide, percutaneous coronary intervention, radial artery",
author = "Rayyan Hemetsberger and A. P{\'o}sa and Serdar Farhan and Hani Hemetsberger and Bassam Redwan and Noemi Pavo and Pavo, {Imre J.} and Plass, {Christian A.} and {\"O}rs Petnehazy and Zsolt Petrasi and Kurt Huber and Dietmar Glogar and Gerald Maurer and Mariann Gyngysi",
year = "2011",
month = "1",
doi = "10.1016/j.jcin.2010.09.018",
language = "English",
volume = "4",
pages = "98--106",
journal = "JACC: Cardiovascular Interventions",
issn = "1936-8798",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Drug-eluting introducer sheath prevents local peripheral complications

AU - Hemetsberger, Rayyan

AU - Pósa, A.

AU - Farhan, Serdar

AU - Hemetsberger, Hani

AU - Redwan, Bassam

AU - Pavo, Noemi

AU - Pavo, Imre J.

AU - Plass, Christian A.

AU - Petnehazy, Örs

AU - Petrasi, Zsolt

AU - Huber, Kurt

AU - Glogar, Dietmar

AU - Maurer, Gerald

AU - Gyngysi, Mariann

PY - 2011/1

Y1 - 2011/1

N2 - Objectives This study evaluated the protective effect of nitric oxidecoating of introducer sheath on the local complications in juvenile porcine femoral arteries with similar size to human radial arteries. Background Insertion of an introducer sheath induces vasospasm and transient or permanent vessel occlusion of radial arteries. Methods Nitric oxidecoated or control introducer sheaths with or without spasmolytic cocktail (control + C-sheath) were inserted into porcine femoral arteries, followed by percutaneous coronary intervention (PCI). The diameter of the femoral artery at the puncture site, distally and proximally, was measured by quantitative angiography. Histopathological and histomorphometric parameters of the femoral arteries were analyzed 1 h or 1 week after PCI. Results Insertion of femoral sheath led to mild or severe spasms, with significantly higher vessel diameter at the access site (2.69 ± 0.81 mm vs. 1.77 ± 0.77 mm and 1.85 ± 0.66 mm, p <0.001), and proximal and distal to it, during PCI in the nitric oxidesheath group versus the control-sheath and control + C-sheath groups, respectively. Immediately following PCI, significantly less luminal thrombosis (12% vs. 33% and 31% of all analyzed segments, p <0.001) was observed in the nitric oxidesheath arteries. At 1 week, lower intimal inflammation score (0.43 ± 11 vs. 1.03 ± 0.35 and 1.04 ± 0.32, p <0.05), less luminal thrombosis (8% vs. 21% and 30% p <0.05), and smaller intimal hyperplasia (0.31 ± 0.31 mm2 vs. 0.47 ± 1.00 mm 2 and 0.86 ± 0.82 mm2, p <0.05) were observed in NO-sheath arteries at the injury site. Conclusions Nitric oxide coating on the introducer sheath prevents local complications during PCI and results in less vascular thrombosis and inflammation at the access site, contributing to patency of the access vessel with similar size to the radial artery.

AB - Objectives This study evaluated the protective effect of nitric oxidecoating of introducer sheath on the local complications in juvenile porcine femoral arteries with similar size to human radial arteries. Background Insertion of an introducer sheath induces vasospasm and transient or permanent vessel occlusion of radial arteries. Methods Nitric oxidecoated or control introducer sheaths with or without spasmolytic cocktail (control + C-sheath) were inserted into porcine femoral arteries, followed by percutaneous coronary intervention (PCI). The diameter of the femoral artery at the puncture site, distally and proximally, was measured by quantitative angiography. Histopathological and histomorphometric parameters of the femoral arteries were analyzed 1 h or 1 week after PCI. Results Insertion of femoral sheath led to mild or severe spasms, with significantly higher vessel diameter at the access site (2.69 ± 0.81 mm vs. 1.77 ± 0.77 mm and 1.85 ± 0.66 mm, p <0.001), and proximal and distal to it, during PCI in the nitric oxidesheath group versus the control-sheath and control + C-sheath groups, respectively. Immediately following PCI, significantly less luminal thrombosis (12% vs. 33% and 31% of all analyzed segments, p <0.001) was observed in the nitric oxidesheath arteries. At 1 week, lower intimal inflammation score (0.43 ± 11 vs. 1.03 ± 0.35 and 1.04 ± 0.32, p <0.05), less luminal thrombosis (8% vs. 21% and 30% p <0.05), and smaller intimal hyperplasia (0.31 ± 0.31 mm2 vs. 0.47 ± 1.00 mm 2 and 0.86 ± 0.82 mm2, p <0.05) were observed in NO-sheath arteries at the injury site. Conclusions Nitric oxide coating on the introducer sheath prevents local complications during PCI and results in less vascular thrombosis and inflammation at the access site, contributing to patency of the access vessel with similar size to the radial artery.

KW - drug-coating

KW - introducer sheath

KW - nitric oxide

KW - percutaneous coronary intervention

KW - radial artery

UR - http://www.scopus.com/inward/record.url?scp=78751663396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78751663396&partnerID=8YFLogxK

U2 - 10.1016/j.jcin.2010.09.018

DO - 10.1016/j.jcin.2010.09.018

M3 - Article

VL - 4

SP - 98

EP - 106

JO - JACC: Cardiovascular Interventions

JF - JACC: Cardiovascular Interventions

SN - 1936-8798

IS - 1

ER -