Drug delivery approaches for apigenin: A review

Zsójia Edit Pápay, Emese Balogh, Mohammed Gulrez Zariwala, Satyanarayana Somavarapu, I. Antal

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Apigenin is a naturally occurring plant flavone with prominent antioxidant and antiinflammatory properties. Although apigenin has the potential to be a promising molecule also for cancer treatment, its delivery to the body requires suitable dosage form design due to physicochemical characteristics that lead to poor bioavailability. It is classified as a BCS (Biopharmaceutical Classification System) II drug with low water solubility and high lipophilicity. Improving the solubility of apigenin is crucial, various formulation approaches have recently been employed e.g., nanocrystals have increased dissolution rate and antioxidant activity, while polymeric micelles increased the solubility to 148 times higher than that crude apigenin and showed enhanced cytotoxicity on hepatoma cells. PLGA encapsulated apigenin nanoparticles cause mitochondrial apoptosis and even DNA targeting could be achieved in skin cancer. The chapter reviews current approaches to the formulation of drug delivery systems containing apigenin.

Original languageEnglish
Title of host publicationApigenin and Naringenin: Natural Sources, Pharmacology and Role in Cancer Prevention
PublisherNova Science Publishers, Inc.
Pages1-20
Number of pages20
ISBN (Print)9781634639958, 9781634639873
Publication statusPublished - Jan 1 2015

Fingerprint

Apigenin
Drug delivery
Pharmaceutical Preparations
Solubility
flavone
Nanoparticles
Antioxidants
Oncology
Dosage Forms
Micelles
Skin Neoplasms
Drug Delivery Systems
Cytotoxicity
Nanocrystals
Biological Availability
Hepatocellular Carcinoma
Skin
Dissolution
Anti-Inflammatory Agents
Apoptosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Pápay, Z. E., Balogh, E., Zariwala, M. G., Somavarapu, S., & Antal, I. (2015). Drug delivery approaches for apigenin: A review. In Apigenin and Naringenin: Natural Sources, Pharmacology and Role in Cancer Prevention (pp. 1-20). Nova Science Publishers, Inc..

Drug delivery approaches for apigenin : A review. / Pápay, Zsójia Edit; Balogh, Emese; Zariwala, Mohammed Gulrez; Somavarapu, Satyanarayana; Antal, I.

Apigenin and Naringenin: Natural Sources, Pharmacology and Role in Cancer Prevention. Nova Science Publishers, Inc., 2015. p. 1-20.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pápay, ZE, Balogh, E, Zariwala, MG, Somavarapu, S & Antal, I 2015, Drug delivery approaches for apigenin: A review. in Apigenin and Naringenin: Natural Sources, Pharmacology and Role in Cancer Prevention. Nova Science Publishers, Inc., pp. 1-20.
Pápay ZE, Balogh E, Zariwala MG, Somavarapu S, Antal I. Drug delivery approaches for apigenin: A review. In Apigenin and Naringenin: Natural Sources, Pharmacology and Role in Cancer Prevention. Nova Science Publishers, Inc. 2015. p. 1-20
Pápay, Zsójia Edit ; Balogh, Emese ; Zariwala, Mohammed Gulrez ; Somavarapu, Satyanarayana ; Antal, I. / Drug delivery approaches for apigenin : A review. Apigenin and Naringenin: Natural Sources, Pharmacology and Role in Cancer Prevention. Nova Science Publishers, Inc., 2015. pp. 1-20
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