Drug delivery approaches for apigenin: A review

Zsójia Edit Pápay, Emese Balogh, Mohammed Gulrez Zariwala, Satyanarayana Somavarapu, István Antal

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


Apigenin is a naturally occurring plant flavone with prominent antioxidant and antiinflammatory properties. Although apigenin has the potential to be a promising molecule also for cancer treatment, its delivery to the body requires suitable dosage form design due to physicochemical characteristics that lead to poor bioavailability. It is classified as a BCS (Biopharmaceutical Classification System) II drug with low water solubility and high lipophilicity. Improving the solubility of apigenin is crucial, various formulation approaches have recently been employed e.g., nanocrystals have increased dissolution rate and antioxidant activity, while polymeric micelles increased the solubility to 148 times higher than that crude apigenin and showed enhanced cytotoxicity on hepatoma cells. PLGA encapsulated apigenin nanoparticles cause mitochondrial apoptosis and even DNA targeting could be achieved in skin cancer. The chapter reviews current approaches to the formulation of drug delivery systems containing apigenin.

Original languageEnglish
Title of host publicationApigenin and Naringenin
Subtitle of host publicationNatural Sources, Pharmacology and Role in Cancer Prevention
PublisherNova Science Publishers, Inc.
Number of pages20
ISBN (Electronic)9781634639958
ISBN (Print)9781634639873
Publication statusPublished - Jan 1 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Pápay, Z. E., Balogh, E., Zariwala, M. G., Somavarapu, S., & Antal, I. (2015). Drug delivery approaches for apigenin: A review. In Apigenin and Naringenin: Natural Sources, Pharmacology and Role in Cancer Prevention (pp. 1-20). Nova Science Publishers, Inc..