Drift diffusion model of reward and punishment learning in rare alpha-synuclein gene carriers

Ahmed A. Moustafa, S. Kéri, Bertalan Polner, Corey White

Research output: Contribution to journalArticle

Abstract

To understand the cognitive effects of alpha-synuclein polymorphism, we employed a drift diffusion model (DDM) to analyze reward- and punishment-guided probabilistic learning task data of participants with the rare alpha-synuclein gene duplication and age- and education-matched controls. Overall, the DDM analysis showed that, relative to controls, asymptomatic alpha-synuclein gene duplication carriers had significantly increased learning from negative feedback, while they tended to show impaired learning from positive feedback. No significant differences were found in response caution, response bias, or motor/encoding time. We here discuss the implications of these computational findings to the understanding of the neural mechanism of alpha-synuclein gene duplication.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of Neurogenetics
DOIs
Publication statusAccepted/In press - Mar 17 2017

Fingerprint

alpha-Synuclein
Punishment
Reward
Gene Duplication
Learning
Genes
Education
Formative Feedback

Keywords

  • Alpha-synuclein gene
  • drift diffusion model
  • Parkinson’s disease
  • punishment
  • reinforcement learning
  • reward

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics
  • Cellular and Molecular Neuroscience

Cite this

Drift diffusion model of reward and punishment learning in rare alpha-synuclein gene carriers. / Moustafa, Ahmed A.; Kéri, S.; Polner, Bertalan; White, Corey.

In: Journal of Neurogenetics, 17.03.2017, p. 1-6.

Research output: Contribution to journalArticle

@article{52f34cf0b5f0439781c30ed579234b4d,
title = "Drift diffusion model of reward and punishment learning in rare alpha-synuclein gene carriers",
abstract = "To understand the cognitive effects of alpha-synuclein polymorphism, we employed a drift diffusion model (DDM) to analyze reward- and punishment-guided probabilistic learning task data of participants with the rare alpha-synuclein gene duplication and age- and education-matched controls. Overall, the DDM analysis showed that, relative to controls, asymptomatic alpha-synuclein gene duplication carriers had significantly increased learning from negative feedback, while they tended to show impaired learning from positive feedback. No significant differences were found in response caution, response bias, or motor/encoding time. We here discuss the implications of these computational findings to the understanding of the neural mechanism of alpha-synuclein gene duplication.",
keywords = "Alpha-synuclein gene, drift diffusion model, Parkinson’s disease, punishment, reinforcement learning, reward",
author = "Moustafa, {Ahmed A.} and S. K{\'e}ri and Bertalan Polner and Corey White",
year = "2017",
month = "3",
day = "17",
doi = "10.1080/01677063.2017.1301939",
language = "English",
pages = "1--6",
journal = "Journal of Neurogenetics",
issn = "0167-7063",
publisher = "Informa Healthcare",

}

TY - JOUR

T1 - Drift diffusion model of reward and punishment learning in rare alpha-synuclein gene carriers

AU - Moustafa, Ahmed A.

AU - Kéri, S.

AU - Polner, Bertalan

AU - White, Corey

PY - 2017/3/17

Y1 - 2017/3/17

N2 - To understand the cognitive effects of alpha-synuclein polymorphism, we employed a drift diffusion model (DDM) to analyze reward- and punishment-guided probabilistic learning task data of participants with the rare alpha-synuclein gene duplication and age- and education-matched controls. Overall, the DDM analysis showed that, relative to controls, asymptomatic alpha-synuclein gene duplication carriers had significantly increased learning from negative feedback, while they tended to show impaired learning from positive feedback. No significant differences were found in response caution, response bias, or motor/encoding time. We here discuss the implications of these computational findings to the understanding of the neural mechanism of alpha-synuclein gene duplication.

AB - To understand the cognitive effects of alpha-synuclein polymorphism, we employed a drift diffusion model (DDM) to analyze reward- and punishment-guided probabilistic learning task data of participants with the rare alpha-synuclein gene duplication and age- and education-matched controls. Overall, the DDM analysis showed that, relative to controls, asymptomatic alpha-synuclein gene duplication carriers had significantly increased learning from negative feedback, while they tended to show impaired learning from positive feedback. No significant differences were found in response caution, response bias, or motor/encoding time. We here discuss the implications of these computational findings to the understanding of the neural mechanism of alpha-synuclein gene duplication.

KW - Alpha-synuclein gene

KW - drift diffusion model

KW - Parkinson’s disease

KW - punishment

KW - reinforcement learning

KW - reward

UR - http://www.scopus.com/inward/record.url?scp=85015618156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015618156&partnerID=8YFLogxK

U2 - 10.1080/01677063.2017.1301939

DO - 10.1080/01677063.2017.1301939

M3 - Article

C2 - 28316265

AN - SCOPUS:85015618156

SP - 1

EP - 6

JO - Journal of Neurogenetics

JF - Journal of Neurogenetics

SN - 0167-7063

ER -