Dramatic impact of ppb levels of palladium on the "copper- catalyzed" sonogashira coupling

Zsombor Gonda, Gergely L. Tolnai, Zoltán Novák

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Palladacadabra! The effect of ppb levels of palladium on the "copper-catalyzed" Sonogashira coupling is reported. The observed high sensitivity to palladium impurities queries the existence of pure copper catalysis in the coupling of aryl iodides and terminal acetylenes (see figure).

Original languageEnglish
Pages (from-to)11822-11826
Number of pages5
JournalChemistry - A European Journal
Volume16
Issue number39
DOIs
Publication statusPublished - Oct 18 2010

Keywords

  • alkynes
  • copper
  • cross-coupling
  • palladium
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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