Dramatic changes in the serum levels of anti-cholesterol antibodies after eversion endarterectomy in patients with severe carotid atherosclerosis

Adrienn Bíró, Edit Dósa, A. Horváth, Z. Prohászka, Szabolcs Rugonfalvi-Kiss, Attila Szabó, I. Karádi, G. Acsády, László Selmeczi, L. Entz, G. Füst, László Romics

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Our goal was to study changes in anti-cholesterol antibodies (ACHA) levels in patients with severe carotid stenosis after eversion endarterectomy. Seventy consecutive patients who underwent eversion endarterectomy at the Department of Cardiovascular Surgery, Semmelweis University, Budapest, were included in the study. Serum samples from 66 healthy volunteers served as controls. Patients had medical check up at 5.7 (4.6-8.0) weeks (median (interquartile range)), 6.8 (6.2-7.9) months as well as 13.8 (12.3-19.0) months after endarterectomy. In all patients the carotid arteries were investigated by color duplex ultrasound. ACHA concentrations were determined in the serum samples taken before operation as well as at the first and last follow-up visits by using an ELISA method. ACHA concentrations (median (interquartile range) were found to be significantly (p <0.0001) lower in the sera of the patients with carotid atherosclerosis (13.5 (8.4-21.3) AU/ml) than in the healthy subjects (26.1 (20.9-33.2) AU/ml) (Mann-Whitney test). Strong negative correlation was found between the preoperative ACHA and LDL-cholesterol levels (r = -0.413, p = 0.0004). Serum ACHA concentrations significantly (p <0.0001) increased from the values measured before operation (13.5 (8.4-21.3) AU/ml) to 27.1 (19.9-34.7) AU/ml measured at the end of the 14 months long follow-up. Increase occurred only in patients with low or medium baseline ACHA concentration. Our present findings indicate that after surgical removal of atherosclerotic plaques from the carotid arteries the reduced baseline levels of ACHA reach normal values in 1 year. Different not mutually exclusive mechanisms (binding of ACHA to lipid/lipoproteins particles, to advanced plaques or reversibly injured endothelial cells in CNS) can be responsible for this novel finding.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalImmunology Letters
Volume99
Issue number1
DOIs
Publication statusPublished - Jun 15 2005

Fingerprint

Endarterectomy
Carotid Artery Diseases
Anti-Idiotypic Antibodies
Cholesterol
Serum
Carotid Arteries
Healthy Volunteers
Carotid Stenosis
Atherosclerotic Plaques
LDL Cholesterol
Lipoproteins
Reference Values
Endothelial Cells
Color
Enzyme-Linked Immunosorbent Assay
Lipids

Keywords

  • Anti-cholesterol antibody
  • Endarterectomy
  • Stroke

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Dramatic changes in the serum levels of anti-cholesterol antibodies after eversion endarterectomy in patients with severe carotid atherosclerosis. / Bíró, Adrienn; Dósa, Edit; Horváth, A.; Prohászka, Z.; Rugonfalvi-Kiss, Szabolcs; Szabó, Attila; Karádi, I.; Acsády, G.; Selmeczi, László; Entz, L.; Füst, G.; Romics, László.

In: Immunology Letters, Vol. 99, No. 1, 15.06.2005, p. 51-56.

Research output: Contribution to journalArticle

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AU - Rugonfalvi-Kiss, Szabolcs

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AU - Acsády, G.

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