Doxorubicin nanocarriers based on magnetic colloids with a bio-polyelectrolyte corona and high non-linear optical response: Synthesis, characterization, and properties

Aristides Bakandritsos, George Mattheolabakis, George Chatzikyriakos, T. Szabó, Vasilis Tzitzios, Dimitris Kouzoudis, Stelios Couris, Konstantinos Avgoustakis

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Magnetic drug nanocarriers are synthesized following an arrested mineralization of magnetic spinel iron oxides in the presence of the biopolymer of sodium carboxymethylcellulose. Based on the experimental results, the polyelectrolyte corona probably attains a brushlike configuration around the magnetic particles. The inner core of these colloids may be constituted of polymer-associated nanocrystallites, forming nanogel colloids. The hybrid colloids are endowed with a high loading capacity for the anticancer agent doxorubicin and pronounced pH responsiveness. They also display a dramatic increase in non-linear optical response as compared to previous studies of similar materials. Furthermore, as cell studies indicate, the blank nanocarriers are cytocompatible and the drug retains its activity after loading in the nanocarriers.

Original languageEnglish
Pages (from-to)1465-1475
Number of pages11
JournalAdvanced Functional Materials
Volume21
Issue number8
DOIs
Publication statusPublished - Apr 22 2011

Fingerprint

Colloids
Polyelectrolytes
Doxorubicin
coronas
colloids
drugs
synthesis
Nanocrystallites
Carboxymethylcellulose Sodium
Biopolymers
biopolymers
blanks
Iron oxides
iron oxides
Pharmaceutical Preparations
Antineoplastic Agents
Particles (particulate matter)
spinel
Polymers
Sodium

Keywords

  • biomedical applications
  • colloids
  • hybrid materials
  • magnetic nanoparticles
  • non-linear optics

ASJC Scopus subject areas

  • Biomaterials
  • Electrochemistry
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Doxorubicin nanocarriers based on magnetic colloids with a bio-polyelectrolyte corona and high non-linear optical response : Synthesis, characterization, and properties. / Bakandritsos, Aristides; Mattheolabakis, George; Chatzikyriakos, George; Szabó, T.; Tzitzios, Vasilis; Kouzoudis, Dimitris; Couris, Stelios; Avgoustakis, Konstantinos.

In: Advanced Functional Materials, Vol. 21, No. 8, 22.04.2011, p. 1465-1475.

Research output: Contribution to journalArticle

Bakandritsos, Aristides ; Mattheolabakis, George ; Chatzikyriakos, George ; Szabó, T. ; Tzitzios, Vasilis ; Kouzoudis, Dimitris ; Couris, Stelios ; Avgoustakis, Konstantinos. / Doxorubicin nanocarriers based on magnetic colloids with a bio-polyelectrolyte corona and high non-linear optical response : Synthesis, characterization, and properties. In: Advanced Functional Materials. 2011 ; Vol. 21, No. 8. pp. 1465-1475.
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