Down's syndrome in twins

Research output: Contribution to journalArticle

Abstract

Studies of twins with Down's syndrome might be expected to give useful evidence for etiology determination. Some 500 pairs of twins have been known so far in the literature where one or both of the twins were afflicted with the syndrome. In the past five years we examined newborns with Down's syndrome. Of these, 13 regular trisomy 21 originated from twin pregnancies. In only one case was concordance experienced, while 11 diseased children's cotwins were healthy. Of the 12 twin pairs, 7 were in all probability MZ (including the concordant pair). The results show, in agreement with the literature, that MZ twins show concordance for trisomy 21 to a lesser extent than expected. No deviation was found in the distribution of maternal age of newborns with Down's syndrome originating from twin pregnancy when comparing them with cases of single births. Their birth weight percentile values were lower than 25.

Original languageEnglish
Pages (from-to)43
Number of pages1
JournalActa Geneticae Medicae et Gemellologiae
Volume23
Issue numberSpec Nr
Publication statusPublished - 1974

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Down Syndrome
Twin Pregnancy
Newborn Infant
Twin Studies
Maternal Age
Birth Weight
Parturition

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Down's syndrome in twins. / Papp, Z.

In: Acta Geneticae Medicae et Gemellologiae, Vol. 23, No. Spec Nr, 1974, p. 43.

Research output: Contribution to journalArticle

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