Down's syndrome: chromosome analysis of 362 cases in Hungary

Z. Papp, M. Osztovics, D. Schuler, K. Méhes, E. Czeizel, L. Horváth, G. Szemere, J. László

Research output: Contribution to journalArticle

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Abstract

A survey is given of the karyotypes observed in 362 children clinically diagnosed as cases of Down's syndrome from whom material was sent to 8 collaborating cytogenetic laboratories in Hungary during the period 1965-1974. The sample studied cytogenetically constitutes about 20% of all children born in Hungary in this decade with Down's syndrome. The ways in which patients were selected for cytogenetic examinations could not be specified. In the sample, standard trisomy 21 was found in 91.7%, translocations in 3.9% and mosaicism in 4.4%. The mean age of the mothers of the children investigated was 29.05 yr, a relatively low figure which may be explained by the decrease of the mean maternal age over the last decades.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalHuman Heredity
Volume27
Issue number5
Publication statusPublished - 1977

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Hungary
Down Syndrome
Chromosomes
Cytogenetics
Mosaicism
Maternal Age
Karyotype
Mothers

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Down's syndrome : chromosome analysis of 362 cases in Hungary. / Papp, Z.; Osztovics, M.; Schuler, D.; Méhes, K.; Czeizel, E.; Horváth, L.; Szemere, G.; László, J.

In: Human Heredity, Vol. 27, No. 5, 1977, p. 305-309.

Research output: Contribution to journalArticle

Papp, Z, Osztovics, M, Schuler, D, Méhes, K, Czeizel, E, Horváth, L, Szemere, G & László, J 1977, 'Down's syndrome: chromosome analysis of 362 cases in Hungary', Human Heredity, vol. 27, no. 5, pp. 305-309.
Papp, Z. ; Osztovics, M. ; Schuler, D. ; Méhes, K. ; Czeizel, E. ; Horváth, L. ; Szemere, G. ; László, J. / Down's syndrome : chromosome analysis of 362 cases in Hungary. In: Human Heredity. 1977 ; Vol. 27, No. 5. pp. 305-309.
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