Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors

Narasimman Gurusamy, I. Lekli, Md Kaimul Ahsan, Diptarka Ray, Subhendu Mukherjee, Eduardo Mascareno, M. A Q Siddiqui, Dipak K. Das

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

CLP-1, the mouse homologue of human Hexim1 protein, exerts inhibitory control on transcriptional elongation factor-b of RNA transcript elongation. Previously, we have demonstrated that downregulation of cardiac lineage protein-1 (CLP-1) in CLP-1+/- heterozygous mice affords cardioprotection against ischemia-reperfusion injury. Our current study results show that the improvement in cardiac function in CLP-1+/- mice after ischemia-reperfusion injury is achieved through the potentiation of redox signaling and their molecular targets including redox effector factor-1, nuclear factor erythroid 2-related factor, and NADPH oxidase 4 and the active usage of thioredoxin-1, thioredoxin-2, glutaredoxin-1 and glutaredoxin-2. Our results suggest that drugs designed to down regulate CLP-1 could confer cardioprotection through the potentiation of redox cycling.

Original languageEnglish
Pages (from-to)187-193
Number of pages7
JournalFEBS Letters
Volume584
Issue number1
DOIs
Publication statusPublished - Jan 4 2010

Fingerprint

Glutaredoxins
Oxidation-Reduction
Thioredoxins
Up-Regulation
Down-Regulation
Reperfusion Injury
Transcriptional Elongation Factors
GATA1 Transcription Factor
Proteins
NADPH Oxidase
Elongation
RNA
Pharmaceutical Preparations
Mouse Hexim1 protein

Keywords

  • Cardiac
  • Cardiac lineage protein-1
  • Hexim1
  • Ischemia-reperfusion
  • Nuclear factor erythroid 2-related factor
  • Redox factor
  • Ref-1
  • Thioredoxin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors. / Gurusamy, Narasimman; Lekli, I.; Ahsan, Md Kaimul; Ray, Diptarka; Mukherjee, Subhendu; Mascareno, Eduardo; Siddiqui, M. A Q; Das, Dipak K.

In: FEBS Letters, Vol. 584, No. 1, 04.01.2010, p. 187-193.

Research output: Contribution to journalArticle

Gurusamy, N, Lekli, I, Ahsan, MK, Ray, D, Mukherjee, S, Mascareno, E, Siddiqui, MAQ & Das, DK 2010, 'Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors', FEBS Letters, vol. 584, no. 1, pp. 187-193. https://doi.org/10.1016/j.febslet.2009.11.054
Gurusamy, Narasimman ; Lekli, I. ; Ahsan, Md Kaimul ; Ray, Diptarka ; Mukherjee, Subhendu ; Mascareno, Eduardo ; Siddiqui, M. A Q ; Das, Dipak K. / Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors. In: FEBS Letters. 2010 ; Vol. 584, No. 1. pp. 187-193.
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