Down-regulation of toll-like receptor TLR4 Is associated with HPV DNA integration in penile carcinoma

Miklos Damasdi, Krisztina Kovacs, Nelli Farkas, F. Jakab, Gyula Kovacs

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aim: Development of penile cancers is attributed to HPV-related carcinogenesis. Our aim was to analyze HPV positivity and TLR4, p16ink4a and p53 expression. Materials and Methods: HPV presence was assessed with virus-specific TaqMan PCR and HPV Genotyping Test in 31 penile cancers. Immunohistochemistry was carried out on tissue microarray. Results: TLR4 expression was detected in 4 of the 16 HPV positive and 13 of the 15 HPV negative tumors. We found a significant inverse correlation between HPV positivity and TLR4 expression (p=0.0006). Ten of the 16 HPV-positive but none of the 15 HPV-negative tumors expressed p16INK4a. A significant correlation was seen between p53 expression and lack of HPV DNA (p=0.0191) as well as between TLR4 and p53 expression (p=0.0198) in penile cancers. Conclusion: Our findings suggest a protective role of TLR4 expression against HPV DNA integration and the viral and non-viral carcinogenesis of penile cancer.

Original languageEnglish
Pages (from-to)5515-5519
Number of pages5
JournalAnticancer Research
Volume37
Issue number10
DOIs
Publication statusPublished - Oct 1 2017

Fingerprint

Penile Neoplasms
Toll-Like Receptors
Down-Regulation
Carcinoma
Human papillomavirus 16
DNA
Carcinogenesis
Virus Integration
Viral DNA
Neoplasms
Immunohistochemistry
Viruses
Polymerase Chain Reaction

Keywords

  • HPV
  • Immunohistochemistry
  • P53
  • Penile cancer
  • TLR4

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Down-regulation of toll-like receptor TLR4 Is associated with HPV DNA integration in penile carcinoma. / Damasdi, Miklos; Kovacs, Krisztina; Farkas, Nelli; Jakab, F.; Kovacs, Gyula.

In: Anticancer Research, Vol. 37, No. 10, 01.10.2017, p. 5515-5519.

Research output: Contribution to journalArticle

Damasdi, Miklos ; Kovacs, Krisztina ; Farkas, Nelli ; Jakab, F. ; Kovacs, Gyula. / Down-regulation of toll-like receptor TLR4 Is associated with HPV DNA integration in penile carcinoma. In: Anticancer Research. 2017 ; Vol. 37, No. 10. pp. 5515-5519.
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