Dosimetric evaluation of high-dose-rate interstitial brachytherapy boost treatments for localized prostate cancer

Georgina Fröhlich, Péter Ágoston, József Lövey, András Somogyi, János Fodor, Csaba Polgár, Tibor Major

Research output: Contribution to journalArticle

10 Citations (Scopus)


Purpose: To quantitatively evaluate the dose distributions of high-dose-rate (HDR) prostate implants regarding target coverage, dose homogeneity, and dose to organs at risk. Material and Methods: Treatment plans of 174 implants were evaluated using cumulative dose-volume histograms (DVHs). The planning was based on transrectal ultrasound (US) imaging, and the prescribed dose (100%) was 10 Gy. The tolerance doses to rectum and urethra were 80% and 120%, respectively. Dose-volume parameters for target (V90, V100, V150, V200, D90, Dmin) and quality indices (DNR [dose nonuniformity ratio], DHI [dose homogeneity index], CI [coverage index], COIN [conformal index]) were calculated. Maximum dose in reference points of rectum (D r) and urethra (Du), dose to volume of 2 cm3 of the rectum (D2ccm), and 0.1 cm3 and 1% of the urethra (D0.1ccm and D1) were determined. Nonparametric correlation analysis was performed between these parameters. Results: The median number of needles was 16, the mean prostate volume (Vp) was 27.1 cm3. The mean V90, V100, V150, and V200 were 99%, 97%, 39%, and 13%, respectively. The mean D90 was 109%, and the Dmin was 87%. The mean doses in rectum and urethra reference points were 75% and 119%, respectively. The mean volumetric doses were D2ccm = 49% for the rectum, D0.1ccm = 126%, and D1 = 140% for the urethra. The mean DNR was 0.37, while the DHI was 0.60. The mean COIN was 0.66. The Spearman rank order correlation coefficients for volume doses to rectum and urethra were R(Dr,D2ccm) = 0.69, R(Du,D0.1ccm) = 0.64, R(Du,D1) = 0.23. Conclusion: US-based treatment plans for HDR prostate implants based on the real positions of catheters provided acceptable dose distributions. In the majority of the cases, the doses to urethra and rectum were kept below the defined tolerance levels. For rectum, the dose in reference points correlated well with dose-volume parameters. For urethra dose characterization, the use of D1 volumetric parameter is recommended.

Original languageEnglish
Pages (from-to)388-395
Number of pages8
JournalStrahlentherapie und Onkologie
Issue number7
Publication statusPublished - Jul 1 2010


  • DVH evaluation
  • Dose to organs at risk
  • HDR brachytherapy
  • Prostate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

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