Dose requirements and plasma concentrations of pipecuronium during bilateral renal exclusion and orthotopic liver transplantation in pigs

J. F. Pittet, E. Tassonyi, C. Schopfer, D. R. Morel, P. Leemann, G. Mentha, C. Le Coultre, D. A. Steinig, A. Benakis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have studied five pigs undergoing bilateral clamping of the renal pedicles, seven pigs undergoing orthotopic liver transplantation and three control animals without surgery in order to examine the roles of the kidney and liver in the plasma clearance of pipecuronium. An i.v. infusion of pipecuronium was controlled to maintain a constant 90-95 % twitch depression throughout the investigation. The right sciatic nerve was stimulated continuously with supra-maximal stimuli at 0.1 Hz and the force of the corresponding evoked isometric muscle contraction was recorded continuously. Control pigs needed an infusion rate of pipecuronium 8-10.7 μg kg-1 min-1. In the renal group, it was necessary to reduce the infusion rate of pipecuronium by about 25% after clamping both renal vascular pedicles (P <0.05 compared with controls); in pigs undergoing liver transplantation, it was necessary to reduce the rate by approximately 80% after clamping hepatic vessels (P <0.05 compared with controls and from the period after clamping of renal vessels). After hepatic recirculation, the infusion rate of pipecuronium was increased progressively to a rate which corresponded to 50% of baseline values (P <0.05 compared with the anhepatic phase and from controls). Plasma concentrations of pipecuronium were comparable in the three animal groups and did not change significantly during the study. These data suggest that the liver plays a more important role than the kidney in the plasma clearance of pipecuronium in pigs.

Original languageEnglish
Pages (from-to)779-785
Number of pages7
JournalBritish Journal of Anaesthesia
Volume65
Issue number6
DOIs
Publication statusPublished - Dec 1990

Fingerprint

Pipecuronium
liver transplant
Transplantation
Liver
Liver Transplantation
Dose
Swine
Plasma
kidneys
Kidney
Plasmas
swine
Requirements
Constriction
dosage
Clearance
liver
Vessel
Animals
Necessary

Keywords

  • Neuromuscular relaxants: pipecuronium
  • Pharmacokinetics: pipecuronium, liver transplantation, renal function

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine

Cite this

Dose requirements and plasma concentrations of pipecuronium during bilateral renal exclusion and orthotopic liver transplantation in pigs. / Pittet, J. F.; Tassonyi, E.; Schopfer, C.; Morel, D. R.; Leemann, P.; Mentha, G.; Coultre, C. Le; Steinig, D. A.; Benakis, A.

In: British Journal of Anaesthesia, Vol. 65, No. 6, 12.1990, p. 779-785.

Research output: Contribution to journalArticle

Pittet, J. F. ; Tassonyi, E. ; Schopfer, C. ; Morel, D. R. ; Leemann, P. ; Mentha, G. ; Coultre, C. Le ; Steinig, D. A. ; Benakis, A. / Dose requirements and plasma concentrations of pipecuronium during bilateral renal exclusion and orthotopic liver transplantation in pigs. In: British Journal of Anaesthesia. 1990 ; Vol. 65, No. 6. pp. 779-785.
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