Dose-related induction of rat hepatic drugmetabolizing enzymes by diuron and chlorotoluron, two substituted phenylurea herbicides

Bernadette Schoket, István Vincze

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Dose-related induction of various hepatic drug-metabolizing enzymes has been investigated after shortterm treatment of rats by diuron and chlorotoluron, a dichlorinated and a monochlorinated phenylurea herbicide, respectively. Results suggest that 'saturation' of the induction system of benzo(a)pyrene monooxygenase, 7-ethoxycoumarin O-deethylase and 7-ethoxyresorufin O-deethylase activities may occur in the same range of the molar doses of both compounds, and with the dichlorinated herbicide at much higher activities. Induction of epoxide hydrolase, UDP-glucuronyltransferase and glutathione S-transferases also shows saturation curves in the function of molar doses. However, the structural difference is not reflected in the enhancement of enzyme activities.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalToxicology Letters
Volume50
Issue number1
DOIs
Publication statusPublished - Jan 1990

Keywords

  • Cytochrome P-450-linked mono-oxygenases
  • Epoxide hydrolase
  • Glutathione S-transferases
  • Substituted urea herbicides
  • UDP-glucuronyltransferase

ASJC Scopus subject areas

  • Toxicology

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