Dose-related effect of the oxytocin fragment (prolyl-leucyl-glycinamide) on α-MPT-induced catecholamine disappearance and serotonin level in rat brain

Gyula Szabó, Gábor L. Kovács, Lajos Baláspiri, Gyula Telegdy

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Abstract

Graded doses of Pro-Leu-Gly-NH2 (3.5 × 10-12, 3.5 × 10-11, 3.5 × 10-10 or 3.5 × 10-9 mol) were administered into the lateral cerebral ventricle of rats. The noradrenaline level of the dorsal hippocampus was increased 30 min after a dose of 3.5 × 10-10 mol Pro-Leu-Gly-NH2. The dopamine level was increased in the dorsal hippocampus and in the striatum. The serotonin level was increased in the hypothalamus, in the striatum and decreased in the dorsal hippocampus. The catecholamine disappearance following 350 mg/kg of α-methyl-p-tyrosine indicated an accelerated dopamine disappearance in the striatum for each dose studied, while the hypothalamic noradrenaline disappearance was inhibited by a dose of 3.5 × 10-11 mol of Pro-Leu-Gly-NH2. The data indicate that Pro-Leu-Gly-NH2 induces dose and region-dependent changes in the cerebral monoamine metabolism. The striatal dopamine and hypothalamic serotonin metabolism appeared to be the most sensitive for intraventricular Pro-Leu-Gly-NH2.

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalNeurochemistry international
Volume3
Issue number6
DOIs
Publication statusPublished - 1981

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ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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