Dose-dependent action of corticosteroids on brain serotonin content and passive avoidance behavior

G. Kovács, G. Telegdy, Kálmán Lissák

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Corticosterone, 1.0 and 5.0 mg/kg, improved passive avoidance behavior based on fear versus thirst-conflict situation. Corticosterone, 1.0 mg/kg, increased the serotonin (5-HT) content in the hypothalamus and mesencephalon; 5.0 mg/kg of corticosterone had no effect. Plasma corticosterone level increased in a dosedependent manner after corticosterone treatment. dl-Parachlorophenylalanine (PCPA) impaired passive avoidance behavior and decreased the hypothalamic and mesencephalic 5-HT level. After PCPA treatment, the plasma corticosterone level was slightly increased. PCPA pretreatment was able to prevent the action of 1.0 and 5.0 mg/kg of corticosterone on behavior as well as on brain 5-HT level. Corticosterone, 10.0 mg/kg, impaired passive avoidance behavior, decreased the hypothalamic and mesencephalic 5-HT content, and increased the plasma corticosterone level. Monoamine oxidase inhibitor (nialamide) treatment improved the passive avoidance behavior and increased the 5-HT level in the hypothalamus and mesencephalon. The plasma corticosterone level did not change significantly. Nialamide pretreatment abolished the behavioral action of 10.0 mg/kg of corticosterone as well as its action on brain 5-HT level. A large dose of corticosterone (25.0 mg/kg) and 2.5 mg/kg of 6-dehydro-16-methylenhydrocortisone (6DH) had a similar action on passive avoidance behavior and on brain serotonin level as 10.0 mg/kg of corticosterone; however, the plasma corticosterone level was increased only in corticosterone-treated animals and was significantly decreased after 6DH. 11-Deoxycorticosterone (DOC) at a dose of 25.0 mg/kg was ineffective on passive avoidance behavior and on brain serotonin content, whereas it slightly decreased the plasma corticosterone level. Data suggest that the corticosterone has dosedependent dual action on passive avoidance behavior, and its action is, at least partly, mediated via changed brain serotonin metabolism. The action seems to be a glucocorticoid-specific one since mineralocorticoid (DOC) is ineffective on this behavioral pattern.

Original languageEnglish
Pages (from-to)155-165
Number of pages11
JournalHormones and Behavior
Volume8
Issue number2
DOIs
Publication statusPublished - 1977

Fingerprint

Avoidance Learning
Corticosterone
Serotonin
Adrenal Cortex Hormones
Brain
Nialamide
Desoxycorticosterone
Mesencephalon
Hypothalamus
Thirst
Mineralocorticoids
Monoamine Oxidase Inhibitors

ASJC Scopus subject areas

  • Endocrinology
  • Behavioral Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Dose-dependent action of corticosteroids on brain serotonin content and passive avoidance behavior. / Kovács, G.; Telegdy, G.; Lissák, Kálmán.

In: Hormones and Behavior, Vol. 8, No. 2, 1977, p. 155-165.

Research output: Contribution to journalArticle

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