### Abstract

We shall assume, of course, that the objective of hyperthermia is to destroy the malignant cells. Destruction definitely needs energy. Description and quality assurance of hyperthermia use the Pennes heat equation to describe the processes. However the energy balance of the Pennes-equation does not contain the hyperthermic cell-destruction energy, which is a mandatory factor of the process. We propose a generalization of the Pennes-equation, inducing the entire energy balance. The new paradigm could be a theoretical basis of the till now empirical dose-construction for oncological hyperthermia. The cell destruction is a non-equilibrium thermodynamical process, described by the equations of chemical reactions. The dynamic behavior (time dependence) has to be considered in this approach. We are going to define also a dose concept that can be objectively compared with other oncological methods. We show how such empirical dose as CEM43oC could be based theoretically as well.

Original language | English |
---|---|

Pages (from-to) | 171-181 |

Number of pages | 11 |

Journal | Journal of Cancer Research and Therapeutics |

Volume | 2 |

Issue number | 4 |

Publication status | Published - Oct 1 2006 |

### Fingerprint

### Keywords

- Cell-destruction
- Dose of hyperthermia
- Oncothermia
- Pennes-equation

### ASJC Scopus subject areas

- Oncology
- Radiology Nuclear Medicine and imaging

### Cite this

*Journal of Cancer Research and Therapeutics*,

*2*(4), 171-181.

**Dose concept of oncological hyperthermia : Heat-equation considering the cell destruction.** / Szász, A.; Vincze, Gy.

Research output: Contribution to journal › Article

*Journal of Cancer Research and Therapeutics*, vol. 2, no. 4, pp. 171-181.

}

TY - JOUR

T1 - Dose concept of oncological hyperthermia

T2 - Heat-equation considering the cell destruction

AU - Szász, A.

AU - Vincze, Gy

PY - 2006/10/1

Y1 - 2006/10/1

N2 - We shall assume, of course, that the objective of hyperthermia is to destroy the malignant cells. Destruction definitely needs energy. Description and quality assurance of hyperthermia use the Pennes heat equation to describe the processes. However the energy balance of the Pennes-equation does not contain the hyperthermic cell-destruction energy, which is a mandatory factor of the process. We propose a generalization of the Pennes-equation, inducing the entire energy balance. The new paradigm could be a theoretical basis of the till now empirical dose-construction for oncological hyperthermia. The cell destruction is a non-equilibrium thermodynamical process, described by the equations of chemical reactions. The dynamic behavior (time dependence) has to be considered in this approach. We are going to define also a dose concept that can be objectively compared with other oncological methods. We show how such empirical dose as CEM43oC could be based theoretically as well.

AB - We shall assume, of course, that the objective of hyperthermia is to destroy the malignant cells. Destruction definitely needs energy. Description and quality assurance of hyperthermia use the Pennes heat equation to describe the processes. However the energy balance of the Pennes-equation does not contain the hyperthermic cell-destruction energy, which is a mandatory factor of the process. We propose a generalization of the Pennes-equation, inducing the entire energy balance. The new paradigm could be a theoretical basis of the till now empirical dose-construction for oncological hyperthermia. The cell destruction is a non-equilibrium thermodynamical process, described by the equations of chemical reactions. The dynamic behavior (time dependence) has to be considered in this approach. We are going to define also a dose concept that can be objectively compared with other oncological methods. We show how such empirical dose as CEM43oC could be based theoretically as well.

KW - Cell-destruction

KW - Dose of hyperthermia

KW - Oncothermia

KW - Pennes-equation

UR - http://www.scopus.com/inward/record.url?scp=33846567455&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846567455&partnerID=8YFLogxK

M3 - Article

C2 - 17998700

AN - SCOPUS:33846567455

VL - 2

SP - 171

EP - 181

JO - Journal of Cancer Research and Therapeutics

JF - Journal of Cancer Research and Therapeutics

SN - 0973-1482

IS - 4

ER -