Dose concept of oncological hyperthermia: Heat-equation considering the cell destruction

A. Szász, Gy Vincze

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We shall assume, of course, that the objective of hyperthermia is to destroy the malignant cells. Destruction definitely needs energy. Description and quality assurance of hyperthermia use the Pennes heat equation to describe the processes. However the energy balance of the Pennes-equation does not contain the hyperthermic cell-destruction energy, which is a mandatory factor of the process. We propose a generalization of the Pennes-equation, inducing the entire energy balance. The new paradigm could be a theoretical basis of the till now empirical dose-construction for oncological hyperthermia. The cell destruction is a non-equilibrium thermodynamical process, described by the equations of chemical reactions. The dynamic behavior (time dependence) has to be considered in this approach. We are going to define also a dose concept that can be objectively compared with other oncological methods. We show how such empirical dose as CEM43oC could be based theoretically as well.

Original languageEnglish
Pages (from-to)171-181
Number of pages11
JournalJournal of Cancer Research and Therapeutics
Volume2
Issue number4
Publication statusPublished - Oct 1 2006

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Keywords

  • Cell-destruction
  • Dose of hyperthermia
  • Oncothermia
  • Pennes-equation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Dose concept of oncological hyperthermia : Heat-equation considering the cell destruction. / Szász, A.; Vincze, Gy.

In: Journal of Cancer Research and Therapeutics, Vol. 2, No. 4, 01.10.2006, p. 171-181.

Research output: Contribution to journalArticle

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