Dopaminergic-opioidergic interaction is reflected by changes in pituitary hormone secretion in patients with essential hypertension

Alexander Alföldi, Mihály Kárteszi, Katalin Simkó, C. Farsang

Research output: Contribution to journalArticle

Abstract

In a randomized, double-blind crossover study 13 untreated patients with mild essential hypertension were exposed to submaximal bicycle exercise. Sixty minutes before ergometry 10 mg metoclopramide or placebo, and 10 min before exercise 0.4 mg naloxone or placebo, were given intravenously. Plasma adrenocorticotrophic hormone, 13-endorphin and cortisol levels increased significantly after ergometry, whether performed after placebo, naloxone, metoclopramide or metoclopramide + naloxone treatment. However, only naloxone administration potentiated plasma adrenocorticotrophic hormone, 13-endorphin and cortisol responses to workload. Plasma levels of adrenocorticotrophic hormone, [3-endorphin and cortisol were 45 ± 14 pg/ml, 6.2 ± 1.2 pmol/l and 141 ± ng/ml, respectively, after ergometry, when performed after placebo, but these values were increased to 61 ± 10 pg/ml, 11.4 ± 2.8 pmol/l and 207 ± 22 ng/ml, respectively, after naloxone treatment. This naloxone-induced potentiation of hormonal release was blocked by metoclopramide pretreatment, suggesting a close interaction between dopaminergic and opioiderg ic mechanisms, regulating hormonal responses to physical exercise.

Original languageEnglish
Pages (from-to)S387-S388
JournalJournal of Hypertension, Supplement
Volume6
Issue number4
Publication statusPublished - 1988

Fingerprint

Pituitary Hormones
Naloxone
Metoclopramide
Endorphins
Ergometry
Placebos
Adrenocorticotropic Hormone
Hydrocortisone
Exercise
Workload
Double-Blind Method
Cross-Over Studies
Essential Hypertension
Therapeutics

Keywords

  • Dopaminergic
  • Ergometric exercise
  • Opioldergic
  • Pituitary hormones

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology

Cite this

Dopaminergic-opioidergic interaction is reflected by changes in pituitary hormone secretion in patients with essential hypertension. / Alföldi, Alexander; Kárteszi, Mihály; Simkó, Katalin; Farsang, C.

In: Journal of Hypertension, Supplement, Vol. 6, No. 4, 1988, p. S387-S388.

Research output: Contribution to journalArticle

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