Dopamine produced by the stomach may act as a paracrine/autocrine hormone in the rat

Éva Mezey, Graeme Eisenhofer, Stefan Hansson, B. Hunyady, Beth J. Hoffman

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Dopamine (DA) has been suggested to be a protective factor in the gastrointestinal tract but neither a source of DA nor its exact targets of action have been identified. In this study, we demonstrate high levels of DA (and DOPA) which persist after chemical sympathectomy in the gastric juice of rats. Immunostaining and in situ hybridization histochemistry reveal the presence of tyrosine hydroxylase (TH), DA transporter and vesicular monamine transporters in the acid-producing parietal cells. Like DA, TH enzyme activity remains after chemical sympathectomy. We also demonstrate active reuptake and storage of DA that indicates a regulated release of this neurohormone from parietal cells. DA D1b receptor mRNA is the most abundant DA receptor subtype in gastric and duodenal epithelium. Therefore, we suggest that selective DA D1b receptor agonists may be useful adjuncts in the treatment of duodenal and gastric ulcers. Gastric epithelia possess the hallmarks of functional DA neuroendocrine cells, suggesting that DA has an important role in self-protective mechanisms of the gastrointestinal tract. These findings should allow elucidation of DA role in normal and disease states in the stomach and duodenum.

Original languageEnglish
Pages (from-to)336-348
Number of pages13
JournalNeuroendocrinology
Volume67
Issue number5
DOIs
Publication statusPublished - 1998

Fingerprint

Dopamine
Stomach
Hormones
Chemical Sympathectomy
Dopamine Receptors
Tyrosine 3-Monooxygenase
Gastrointestinal Tract
Epithelium
Neuroendocrine Cells
Dopamine Plasma Membrane Transport Proteins
Gastric Juice
Dopamine Agonists
Stomach Ulcer
Duodenal Ulcer
Duodenum
In Situ Hybridization
Neurotransmitter Agents
Messenger RNA
Acids
Enzymes

Keywords

  • Catecholamines
  • Monoamine transporters
  • Parietal cells
  • Peripheral neuroendocrinology
  • Stomach
  • Sympathectomy

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Dopamine produced by the stomach may act as a paracrine/autocrine hormone in the rat. / Mezey, Éva; Eisenhofer, Graeme; Hansson, Stefan; Hunyady, B.; Hoffman, Beth J.

In: Neuroendocrinology, Vol. 67, No. 5, 1998, p. 336-348.

Research output: Contribution to journalArticle

Mezey, Éva ; Eisenhofer, Graeme ; Hansson, Stefan ; Hunyady, B. ; Hoffman, Beth J. / Dopamine produced by the stomach may act as a paracrine/autocrine hormone in the rat. In: Neuroendocrinology. 1998 ; Vol. 67, No. 5. pp. 336-348.
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