A dopamin D4-es receptor hipoxia érzékenységé nek gyermekpszichiátriai vonatkozásai

Translated title of the contribution: Dopamine D4 receptor hypoxia sensitivity and child psychiatric disorders

Mózes Viktor, Bence Melinda, M. Sasvári, Keszler Gergely

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Attention-deficit hyperactivity disorder (ADHD) is one of the most frequent child psychiatric problems with a complex genetic and environmental background. According to the prevailing view, main factors of the disorder are prefrontal dopamine deficiency and incomplete central dopaminergic functioning. Twin studies suggest substantial heritability in the background of the disease, and the studied candidate genes involve components of the dopamine system. Moreover, various noxious pre- and perinatal environmental impacts have been implicated in the pathogenesis of ADHD. Here we review experimental results from epidemiological, tissue and animal studies that assigned a causal role to fetal hypoxia in the development of ADHD and pointed out that the dopaminergic neurotransmission is sensitive to hypoxia. Allelic variants of the D4 dopamine receptor (DRD4) are well characterized risk factors of ADHD. Recently we have reported that hypoxia enhanced the promoter activity of DRD4 gene several fold. These observations suggest that the effect of hypoxia on the dopaminergic neurotransmission might be an important factor in the pathomechanism of ADHD.

Original languageHungarian
Pages (from-to)289-293
Number of pages5
JournalNeuropsychopharmacologia Hungarica
Volume12
Issue number1
Publication statusPublished - Mar 2010

Fingerprint

Dopamine D4 Receptors
Child Psychiatry
Attention Deficit Disorder with Hyperactivity
Synaptic Transmission
Dopamine
Fetal Hypoxia
Gene Components
Twin Studies
Hypoxia
Genes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

Cite this

A dopamin D4-es receptor hipoxia érzékenységé nek gyermekpszichiátriai vonatkozásai. / Viktor, Mózes; Melinda, Bence; Sasvári, M.; Gergely, Keszler.

In: Neuropsychopharmacologia Hungarica, Vol. 12, No. 1, 03.2010, p. 289-293.

Research output: Contribution to journalArticle

Viktor, Mózes ; Melinda, Bence ; Sasvári, M. ; Gergely, Keszler. / A dopamin D4-es receptor hipoxia érzékenységé nek gyermekpszichiátriai vonatkozásai. In: Neuropsychopharmacologia Hungarica. 2010 ; Vol. 12, No. 1. pp. 289-293.
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