Dopamine D2 receptor blockade alters the primary and cognitive components of visual evoked potentials in the monkey, Macaca fascicularis

Andrea Antal, S. Kéri, Ivan Bodis-Wollner

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The effects of sulpiride, a dopamine D2 receptor antagonist, were studied on visual event-related potentials in a monkey performing in a visual oddball task in order to investigate receptor specific mechanisms in visuo- cognitive processes. Following the injection of 0.35 mg/kg sulpiride i.m., the amplitude and latency of the primary (P100) and cognitive (P300) components did not change significantly. When 1.05 mg/kg sulpiride was administered, the latency of the primary and, cognitive components increased. The amplitude of the P100 component decreased, while that of the P300 component increased. These data suggest that D2 receptors play an important role in visuo-cognitive processes in both physiological and pathological conditions such as Parkinson's disease and schizophrenia.

Original languageEnglish
Pages (from-to)179-181
Number of pages3
JournalNeuroscience Letters
Volume232
Issue number3
DOIs
Publication statusPublished - Sep 5 1997

Fingerprint

Sulpiride
Macaca fascicularis
Dopamine D2 Receptors
Visual Evoked Potentials
P300 Event-Related Potentials
Haplorhini
Evoked Potentials
Parkinson Disease
Schizophrenia
Injections

Keywords

  • Dopamine D2 receptors
  • Event-related potentials
  • Monkey
  • Oddball paradigm
  • Parkinson's disease
  • Schizophrenia
  • Sulpiride

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dopamine D2 receptor blockade alters the primary and cognitive components of visual evoked potentials in the monkey, Macaca fascicularis. / Antal, Andrea; Kéri, S.; Bodis-Wollner, Ivan.

In: Neuroscience Letters, Vol. 232, No. 3, 05.09.1997, p. 179-181.

Research output: Contribution to journalArticle

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