Dopamine blocks T-type calcium channels in cultured rat adrenal

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Abstract

Dopamine is known to inhibit aldosterone secretion. In the present study using whole-cell voltage-clamp technique we found that dopamine, bromocriptine and quinpirole inhibit low-threshold (T-type) voltage dependent Ca2+ channels. The inhibition was sustained and reversible, and it was prevented by sulpiride. These findings indicate that the effect of dopamine was mediated via DA2 receptors.

Original languageEnglish
Pages (from-to)511-514
Number of pages4
JournalEndocrinology
Volume134
Issue number1
DOIs
Publication statusPublished - Jan 1994

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ASJC Scopus subject areas

  • Endocrinology

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