Dopamine blocks T-type calcium channels in cultured rat adrenal glomerulosa cells

O. N. Osipenko, P. Várnai, A. Mike, A. Spät, E. Vízi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Dopamine is known to inhibit aldosterone secretion. In the present study using whole-cell voltage-clamp technique we found that dopamine, bromocriptine and quinpirole inhibit low-threshold (T-type) voltage dependent Ca2+ channels. The inhibition was sustained and reversible, and it was prevented by sulpiride. These findings indicate that the effect of dopamine was mediated via DA2 receptors.

Original languageEnglish
Pages (from-to)511-514
Number of pages4
JournalEndocrinology
Volume134
Issue number1
DOIs
Publication statusPublished - Jan 1994

Fingerprint

T-Type Calcium Channels
Zona Glomerulosa
Dopamine
Quinpirole
Sulpiride
Bromocriptine
Patch-Clamp Techniques
Aldosterone

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Dopamine blocks T-type calcium channels in cultured rat adrenal glomerulosa cells. / Osipenko, O. N.; Várnai, P.; Mike, A.; Spät, A.; Vízi, E.

In: Endocrinology, Vol. 134, No. 1, 01.1994, p. 511-514.

Research output: Contribution to journalArticle

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